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  1. 教員研究業績
  2. 製剤学研究室
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Mechanical characteristics of orally disintegrating films: Comparison of folding endurance and tensile properties

https://gifu-pu.repo.nii.ac.jp/records/14299
https://gifu-pu.repo.nii.ac.jp/records/14299
2b020400-6a9b-479e-87b2-5b57d4301bdd
Item type 研究室原著論文(1)
公開日 2020-09-11
タイトル
タイトル Mechanical characteristics of orally disintegrating films: Comparison of folding endurance and tensile properties
言語 en
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言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
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アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
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値 The tensile test is the most widely used method for testing the mechanical characteristics of orally disintegrating films (ODFs). The other available test is the folding endurance (FE) test, which is more suitable for clarifying the actual strength during the manufacturing and dosing. However, the FE test is performed manually, and the FE number it generates has not been adequately analyzed as an index. The aim of this studies were to establish an automatic method for determining the FE number, and to compare the resulting FE numbers with the tensile properties. For this purpose, a desktop-model endurance test machine was used. First, the operating conditions—i.e., the folding angle, the folding speed and the weight requirement were optimized using ODF models. Secondly, the FE of ODFs prepared from three film formers (HPMC, HPC, and PVA) and with insoluble particles (calcium carbonate), plasticizers (glycerin) and APIs (acetaminophen), was evaluated and compared with the tensile properties. Lastly, the commercial ODFs were investigated. The results showed that our automatic system could be successfully used to determine the FE characteristics of ODFs. FE was suggested to relate to not only the strength but also the elongation during the tensile test.
bibliographic_information en : International Journal of Pharmaceutics

巻 589, 号 15, p. 119876-119876, ページ数 1, 発行日 2020-09-11
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