{"created":"2023-06-19T07:26:04.439910+00:00","id":14322,"links":{},"metadata":{"_buckets":{"deposit":"7a997086-248c-47f1-b016-b81134ff37ba"},"_deposit":{"created_by":125,"id":"14322","owners":[125],"pid":{"revision_id":0,"type":"depid","value":"14322"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014322","sets":["212:267:297"]},"author_link":["33329","33338","33336","33331","33335","33337","33334","33330","33332","33333"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"90","bibliographicVolumeNumber":"26","bibliographic_titles":[{},{"bibliographic_title":"Molecules","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":" 10.3390/molecules26010090"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Ferulic Acid (FA) is a highly abundant phenolic phytochemical which is present in plant tissues. FA has biological effects on physiological and pathological processes due to its anti-apoptotic and anti-oxidative properties, however, the detailed mechanism(s) of function is poorly understood. We have identified FA as a molecule that inhibits apoptosis induced by hydrogen peroxide (H2O2) or actinomycin D (ActD) in rat pheochromocytoma, PC12 cell. We also found that FA reduces H2O2-induced reactive oxygen species (ROS) production in PC12 cell, thereby acting as an anti-oxidant. Then, we analyzed FA-mediated signaling responses in rat pheochromocytoma, PC12 cells using antibody arrays for phosphokinase and apoptosis related proteins. This FA signaling pathway in PC12 cells includes inactivation of pro-apoptotic proteins, SMAC/Diablo and Bad. In addition, FA attenuates the cell injury by H2O2 through the inhibition of phosphorylation of the extracellular signal-regulated kinase (ERK). Importantly, we find that FA restores expression levels of brain-derived neurotrophic factor (BDNF), a key neuroprotective effector, in H2O2-treated PC12 cells. As a possible mechanism, FA increases BDNF by regulating microRNA-10b expression following H2O2 stimulation. Taken together, FA has broad biological effects as a neuroprotective modulator to regulate the expression of phosphokinases, apoptosis-related proteins and microRNAs against oxidative stress in PC12 cells."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"125","path":["297"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-09"},"publish_date":"2021-03-09","publish_status":"0","recid":"14322","relation_version_is_last":true,"title":["Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells"],"weko_creator_id":"125","weko_shared_id":-1},"updated":"2023-06-19T07:44:01.736114+00:00"}