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Iodine-mediated direct α-amination of dimethyl methylmalonate using non-protected amines
https://gifu-pu.repo.nii.ac.jp/records/14389
https://gifu-pu.repo.nii.ac.jp/records/14389f3b1aaae-f6b6-4c72-ac53-77df857713b2
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-02 | |||||
| タイトル | ||||||
| タイトル | Iodine-mediated direct α-amination of dimethyl methylmalonate using non-protected amines | |||||
| タイトル | ||||||
| タイトル | Iodine-mediated direct α-amination of dimethyl methylmalonate using non-protected amines | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | In this study, direct C-N bond formation was achieved via the reaction of a di-Me methylmalonate with various amines in the presence of mol. iodine to produce α-aminocarbonyl compounds This versatile methodol. of the α-amination of a carbonyl-containing compound involves the in situ iodination of the di-Me methylmalonate, thus promoting the formation of its enolate isomer, which then facilitates its nucleophilic substitution reaction with an amine. This strategy is highly practical and can be used in industry due to its requirement of only readily available reagents without any pre-preparation of the amines and other substrates. | |||||
| 書誌情報 |
en : Tetrahedron Letters 巻 77, p. 153251, 発行日 2021 |
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