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Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP)
https://gifu-pu.repo.nii.ac.jp/records/14406
https://gifu-pu.repo.nii.ac.jp/records/144065af47d9c-343b-46e9-8baa-c5664186c5a2
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-02 | |||||
| タイトル | ||||||
| タイトル | Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP) | |||||
| タイトル | ||||||
| タイトル | Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | The present study was conducted to survey the influence of canola oil (CAN) ingestion on the steroid hormone production in stroke-prone spontaneously hypertensive rats (SHRSP). Male SHR SP were fed a diet containing 10 wt/wt% soybean oil (SOY, the control) or CAN as the sole dietary fat for 8 weeks. Plasma concentration of luteinizing hormone (LH) was similar in the 2 dietary groups. However, the plasma testosterone level in the CAN group, 1.36 ± 0.271 ng/mL, was lower than in the SOY group, 2.79 ± 0.514 ng/mL (p < 0.05, unpaired t-test; n = 10), and plasma concentration of aldosterone in the CAN group, 345 ± 79.6 pg/mL, was higher than in the SOY group, 159 ± 33.7 pg/mL (p < 0.05, unpaired t-test; n = 10). In the testis, the expressions of mRNA for StAR, CYP11A1, CYP17, 3βHSD and 17βHSD and the amounts of the corresponding proteins were significantly decreased. However, in the adrenal gland, the expressions of mRNA for StAR, CYP11A1, 3βHSD and CYP11B1 in the CAN group were not different from those in the SOY group, but the expression of mRNA and the amount of the corresponding protein for CYP11B2 were increased significantly in the CAN group. These findings are indicative of a peripheral, testicular toxicity of CAN. The decreased testosterone and the concomitantly increased aldos terone may play a role in the aggravation by CAN of the genetic diseases (i.e., metabolic syndrome-like complications) in male SHRSP. |
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| 書誌情報 |
Fundamental Toxicological Sciences en : Fundamental Toxicological Sciences 巻 1, 号 9, p. 7-16, 発行日 2022-01-15 |
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