{"created":"2023-06-19T07:26:09.914094+00:00","id":14470,"links":{},"metadata":{"_buckets":{"deposit":"427029db-ca20-4423-a08b-ac9675c1a5c0"},"_deposit":{"created_by":137,"id":"14470","owners":[137],"pid":{"revision_id":0,"type":"depid","value":"14470"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014470","sets":["212:267:297"]},"author_link":["34248","34252","34251","34250","34249","34247"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"91","bibliographicPageStart":"87","bibliographicVolumeNumber":"172","bibliographic_titles":[{},{"bibliographic_title":"Neuroscience research","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.1016/j.neures.2021.04.004"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Abstract\nPatients with schizophrenia (SCZ) have characteristic personality traits compared with healthy subjects. Genome-wide significant variants for neuroticism have been reported in healthy subjects. However, the associations of these genome-wide neuroticism-associated variants with five-factor personality traits in patients with SCZ are less clear. We investigated the influences of nine independent genome-wide significant variants for neuroticism on five-factor personality traits (neuroticism, extraversion, openness, agreeableness, and conscientiousness) assessed by the NEO Five-Factor Inventory (NEO-FFI) in 107 patients with SCZ and 119 healthy controls (HCs). As expected, patients with SCZ scored significantly higher for neuroticism and lower for extraversion, openness, agreeableness and conscientiousness than HCs (p < 0.05). Of nine neuroticism-associated variants, the T allele at rs4653663 related to lower neuroticism was only significantly associated with lower neuroticism in patients with SCZ (β = -0.27, p = 3.88 × 10-3) and in combined subjects (β = -0.15, p = 0.026). Furthermore, of other personality traits, the genetic variant was significantly associated with higher agreeableness in combined subjects (β = 0.17, p = 9.41×10-3), higher conscientiousness in patients with SCZ (β = 0.21, p = 0.031) and lower conscientiousness in HCs (β = -0.20, p = 0.034), and nominally associated with higher extraversion in patients with SCZ (β = 0.18, p = 0.056) and in combined subjects (β = 0.13, p = 0.051). These outcomes were not affected by clinical variables. We suggest that genome-wide neuroticism-associated variant could be associated with neuroticism as well as other personality traits in schizophrenia."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Extraversion, Psychological","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuroticism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Personality","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Personality Inventory","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Schizophrenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of genome-wide neuroticism-associated variants on five-factor model personality traits in schizophrenia.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of genome-wide neuroticism-associated variants on five-factor model personality traits in schizophrenia.","subitem_title_language":"en"}]},"item_type_id":"3","owner":"137","path":["297"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-04"},"publish_date":"2022-03-04","publish_status":"0","recid":"14470","relation_version_is_last":true,"title":["Effects of genome-wide neuroticism-associated variants on five-factor model personality traits in schizophrenia."],"weko_creator_id":"137","weko_shared_id":-1},"updated":"2023-06-19T07:42:34.179768+00:00"}