{"created":"2023-06-19T07:26:09.955633+00:00","id":14471,"links":{},"metadata":{"_buckets":{"deposit":"1e0cd1e9-53f0-4b71-a277-6f55dcb4e524"},"_deposit":{"created_by":137,"id":"14471","owners":[137],"pid":{"revision_id":0,"type":"depid","value":"14471"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014471","sets":["212:267:297"]},"author_link":["34256","34255","34253","34257","34259","34254","34258"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"64","bibliographic_titles":[{},{"bibliographic_title":"European Psychiatry","bibliographic_titleLang":"en"}]}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Background: Intelligence is inversely associated with schizophrenia (SCZ) and bipolar disorder (BD); it remains unclear whether low intelligence is a cause or consequence. We investigated causal associations of intelligence with SCZ or BD risk and a shared risk between SCZ and BD and SCZ-specific risk.\n\nMethods: To estimate putative causal associations, we performed multi-single nucleotide polymorphism (SNP) Mendelian randomization (MR) using generalized summary-data-based MR (GSMR). Summary-level datasets from five GWASs (intelligence, SCZ vs. control [CON], BD vs. CON, SCZ + BD vs. CON, and SCZ vs. BD; sample sizes of up to 269,867) were utilized.\n\nResults: A strong bidirectional association between risks for SCZ and BD was observed (odds ratio; ORSCZ → BD = 1.47, p = 2.89 × 10-41, ORBD → SCZ = 1.44, p = 1.85 × 10-52). Low intelligence was bidirectionally associated with a high risk for SCZ, with a stronger effect of intelligence on SCZ risk (ORlower intelligence → SCZ = 1.62, p = 3.23 × 10-14) than the reverse (ORSCZ → lower intelligence = 1.06, p = 3.70 × 10-23). Furthermore, low intelligence affected a shared risk between SCZ and BD (OR lower intelligence → SCZ + BD = 1.23, p = 3.41 × 10-5) and SCZ-specific risk (ORlower intelligence → SCZvsBD = 1.64, p = 9.72 × 10-10); the shared risk (ORSCZ + BD → lower intelligence = 1.04, p = 3.09 × 10-14) but not SCZ-specific risk (ORSCZvsBD → lower intelligence = 1.00, p = 0.88) weakly affected low intelligence. Conversely, there was no significant causal association between intelligence and BD risk (p > 0.05).\n\nConclusions: These findings support observational studies showing that patients with SCZ display impairment in premorbid intelligence and intelligence decline. Moreover, a shared factor between SCZ and BD might contribute to impairment in premorbid intelligence and intelligence decline but SCZ-specific factors might be affected by impairment in premorbid intelligence. We suggest that patients with these genetic factors should be categorized as having a cognitive disorder SCZ or BD subtype."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Causal associations of intelligence with schizophrenia and bipolar disorder: A Mendelian randomization analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Causal associations of intelligence with schizophrenia and bipolar disorder: A Mendelian randomization analysis","subitem_title_language":"en"}]},"item_type_id":"3","owner":"137","path":["297"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-04"},"publish_date":"2022-03-04","publish_status":"0","recid":"14471","relation_version_is_last":true,"title":["Causal associations of intelligence with schizophrenia and bipolar disorder: A Mendelian randomization analysis"],"weko_creator_id":"137","weko_shared_id":-1},"updated":"2023-06-19T07:42:33.692154+00:00"}