{"created":"2023-06-19T07:26:09.996498+00:00","id":14472,"links":{},"metadata":{"_buckets":{"deposit":"a1e1f1e5-6d53-4576-8597-579268eec6b4"},"_deposit":{"created_by":137,"id":"14472","owners":[137],"pid":{"revision_id":0,"type":"depid","value":"14472"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014472","sets":["212:267:297"]},"author_link":["34268","34260","34269","34261","34265","34270","34262","34263","34267","34266","34264"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"100444","bibliographicVolumeNumber":"44","bibliographic_titles":[{},{"bibliographic_title":"Drug Metabolism and Pharmacokinetics","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"https://doi.org/10.1016/j.dmpk.2022.100444"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Abstract\nDaptomycin is used to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. Current guidelines recommend higher daptomycin doses (8–10 mg/kg) for severe infections; however, pharmacokinetic (PK) and pharmacodynamic-based dosing strategies are still limited. Therefore, we designed a new optimal daptomycin dosing regimen for patients with MRSA infections using a population PK modeling approach. A total of 110 plasma concentrations from 47 adult patients who received daptomycin in general wards were enrolled for population PK modeling. The target area under the concentration-time curve/minimum inhibitory concentration (MIC) ratio, target peak/MIC ratio, and threshold of the trough concentration for safety were set to >666, >60, and 24.3 mg/L, respectively. Renal function was indicated as a significant covariate for daptomycin clearance. The simulated probability of target attainment was more than 90% at MIC values of 0.25 and 0.5 mg/L in all patients at the standard dose (6 mg/kg). In contrast, comprehensive simulation assessments recommended 10 mg/kg every 24 h in patients with creatinine clearance >60 mL/min for MIC values of 1.0 mg/L. We propose a new simplified daptomycin dosing regimen stratified by renal function and MIC values based on PK model-based simulation analyses. The proposed regimen is expected to maximize clinical efficacy and minimize adverse events."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis","subitem_title_language":"en"}]},"item_type_id":"3","owner":"137","path":["297"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-04"},"publish_date":"2022-03-04","publish_status":"0","recid":"14472","relation_version_is_last":true,"title":["Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis"],"weko_creator_id":"137","weko_shared_id":-1},"updated":"2023-06-19T07:39:35.757243+00:00"}