{"created":"2023-06-19T07:26:11.204566+00:00","id":14506,"links":{},"metadata":{"_buckets":{"deposit":"0647e2e5-e598-4c31-a6f6-4fd223eb1339"},"_deposit":{"created_by":122,"id":"14506","owners":[122],"pid":{"revision_id":0,"type":"depid","value":"14506"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014506","sets":["212:253:333"]},"author_link":["34435","34430","34433","34434","34432","34431"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"102953","bibliographicVolumeNumber":"67","bibliographic_titles":[{},{"bibliographic_title":"Journal of Drug Delivery Science and Technology","bibliographic_titleLang":"en"}]}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"We attempted to improve the solubility of poorly water-soluble drugs by preparing drug-loaded polyvinyl alcohol (PVA) nanofibers as a solid dispersion system via emulsion electrospinning. Probucol (PBC), a poorly water-soluble drug, was used as a model drug. Nanofibers were electrospun using an oil/water (o/w) emulsion consisting of PBC dissolved in an immiscible solvent, such as ethyl acetate, and an aqueous PVA phase. PBC-containing PVA nanofibers with diameters ranging from 300 to 600 nm were obtained by electrospinning from o/w emulsions. The physical properties of the nanofibers were affected by the degrees of polymerization and hydrolysis of the PVA grades. In PVA nanofibers prepared without a surfactant, PBC existed in an amorphous state, and the dissolution of PBC was greatly improved. PBC dissolution was lower in PVA nanofibers with 30% PBC content compared to those with 11% or 20% PBC. In PVA nanofibers prepared using the surfactant polysorbate 80 as an emulsifier, PBC was partially crystallized; however, the PBC was homogenously dispersed, and dissolution was improved, even in PVA nanofibers containing 30% PBC. PVA nanofibers produced by o/w emulsion electrospinning were demonstrated to be suitable solid dispersion systems enabling robust controlled release of poorly water-soluble drugs."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Emulsion-electrospun polyvinyl alcohol nanofibers as a solid dispersion system to improve solubility and control the release of probucol, a poorly water-soluble drug","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Emulsion-electrospun polyvinyl alcohol nanofibers as a solid dispersion system to improve solubility and control the release of probucol, a poorly water-soluble drug","subitem_title_language":"en"}]},"item_type_id":"3","owner":"122","path":["333"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-04"},"publish_date":"2022-03-04","publish_status":"0","recid":"14506","relation_version_is_last":true,"title":["Emulsion-electrospun polyvinyl alcohol nanofibers as a solid dispersion system to improve solubility and control the release of probucol, a poorly water-soluble drug"],"weko_creator_id":"122","weko_shared_id":-1},"updated":"2023-06-19T07:42:15.083522+00:00"}