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Study on Redox Properties and Cytotoxicity of Anthraquinone Derivatives to Understand Antitumor Active Anthracycline Substances
https://gifu-pu.repo.nii.ac.jp/records/14543
https://gifu-pu.repo.nii.ac.jp/records/14543e0012e09-a2e7-4dbd-a332-d6f6392969c1
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-07-01 | |||||
| タイトル | ||||||
| タイトル | Study on Redox Properties and Cytotoxicity of Anthraquinone Derivatives to Understand Antitumor Active Anthracycline Substances | |||||
| タイトル | ||||||
| タイトル | Study on Redox Properties and Cytotoxicity of Anthraquinone Derivatives to Understand Antitumor Active Anthracycline Substances | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anthraquinone derivative | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cyclic voltammogram | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytotoxicity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anthracycline antibiotic | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | anthraquinone derivative | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cyclic voltammogram | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cytotoxicity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | anthracycline antibiotic | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | This study demonstrates the relation between the redox properties and cytotoxicity of anthraquinone derivatives with a hydroxyl and methoxy group. The redox behavior of the anthraquinone derivatives was initially observed via cyclic voltammetry and their characteristics were investigated using molecular orbital calculations. The cytotoxicity of the anthraquinone derivatives was then evaluated using human leukemia HL-60 and H2O2 resistant HP100 cells, and its correlation with the redox properties of these compounds was investigated. Therefore, it was suggested that the anthraquinone derivatives express cytotoxicity through H2O2 production, and that generation of the oxidized radical form influences their cytotoxicity. | |||||
| 書誌情報 |
Chemical and Pharmaceutical Bulletin en : Chemical and Pharmaceutical Bulletin 巻 67, 号 7, p. 717-720, 発行日 2019-07-01 |
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| DOI | ||||||
| 値 | doi.org/10.1248/cpb.c19-00103 | |||||
