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Two new methoxylated flavones isolated from Casimiroa edulis La Llave and their MMP-9 inhibitory activity
https://gifu-pu.repo.nii.ac.jp/records/14555
https://gifu-pu.repo.nii.ac.jp/records/1455596a930ac-b0e6-44fa-9f27-4ea4935e9d76
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-07 | |||||
| タイトル | ||||||
| タイトル | Two new methoxylated flavones isolated from Casimiroa edulis La Llave and their MMP-9 inhibitory activity | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Casimiroa edulis La Llave is known to contain unusual 5,6-dimethoxyflavones bearing a variously oxygenated B-ring. Phytochemical investigation of the leaves and the roots of C. edulis achieved the isolation of two new methoxylated flavones, named casedulones A (1) and B (2), together with 12 known analogues. Their unique structures were established with the aid of spectral analyses and total syntheses. Pre-treatment with 20 µM of 1 and 2 suppressed MMP-9 expression in LPS-mediated THP-1 cells, indicating that the characteristic flavonoids in C. edulis could be potential anti-angiogenics for cancer prevention. | |||||
| 書誌情報 |
en : Natural Product Research p. 1-8, 発行日 2022-03-04 |
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