{"created":"2023-06-19T07:26:12.766995+00:00","id":14555,"links":{},"metadata":{"_buckets":{"deposit":"a3bb6706-a751-4b78-9c2b-87dfdb3fd963"},"_deposit":{"created_by":143,"id":"14555","owners":[143],"pid":{"revision_id":0,"type":"depid","value":"14555"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014555","sets":["212:276:279"]},"author_link":["34659","34660","34658","34656","34661","34657","34654","34655"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographic_titles":[{},{"bibliographic_title":"Natural Product Research","bibliographic_titleLang":"en"}]}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Casimiroa edulis La Llave is known to contain unusual 5,6-dimethoxyflavones bearing a variously oxygenated B-ring. Phytochemical investigation of the leaves and the roots of C. edulis achieved the isolation of two new methoxylated flavones, named casedulones A (1) and B (2), together with 12 known analogues. Their unique structures were established with the aid of spectral analyses and total syntheses. Pre-treatment with 20 µM of 1 and 2 suppressed MMP-9 expression in LPS-mediated THP-1 cells, indicating that the characteristic flavonoids in C. edulis could be potential anti-angiogenics for cancer prevention."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Two new methoxylated flavones isolated from Casimiroa edulis La Llave and their MMP-9 inhibitory activity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Two new methoxylated flavones isolated from Casimiroa edulis La Llave and their MMP-9 inhibitory activity","subitem_title_language":"en"}]},"item_type_id":"3","owner":"143","path":["279"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-07"},"publish_date":"2022-03-07","publish_status":"0","recid":"14555","relation_version_is_last":true,"title":["Two new methoxylated flavones isolated from Casimiroa edulis La Llave and their MMP-9 inhibitory activity"],"weko_creator_id":"143","weko_shared_id":-1},"updated":"2023-06-19T07:41:50.517878+00:00"}