{"created":"2023-06-19T07:26:20.933791+00:00","id":14755,"links":{},"metadata":{"_buckets":{"deposit":"83ba3fbf-b311-4d05-871b-7a12cde8d2c0"},"_deposit":{"created_by":137,"id":"14755","owners":[137],"pid":{"revision_id":0,"type":"depid","value":"14755"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014755","sets":["212:267:297"]},"author_link":["36027","36029","36025","36026","36030","36028","36031"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-01-08","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"105","bibliographicPageStart":"100","bibliographicVolumeNumber":"639","bibliographic_titles":[{},{"bibliographic_title":"Biochemical and biophysical research communications","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"DOI: 10.1016/j.bbrc.2022.11.072"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Although opioids are useful narcotic analgesics in clinical settings, their misuse and addiction in the United States of America and other countries are rapidly increasing. Therefore, the development of abuse-deterrent formulations is an urgent issue. We herein investigated how to select the ratio of an opioid and the opioid receptor antagonist, naloxone in abuse-deterrent formulations for mice. The conditioned place preference (CPP) test was used to evaluate the rewarding effects of abused drugs. The opioids morphine (30 μmol/kg), oxycodone (3 μmol/kg), fentanyl (0.4 μmol/kg), and buprenorphine (0.5 μmol/kg) significantly induced place preference in mice. We also examined the optimal ratio of naloxone and opioids to inhibit the rewarding effects of the latter. Naloxone (3-5 μmol/kg) effectively inhibited place preference induced by the opioids tested. We calculated theoretical drug doses that exerted the same pharmacodynamic effects based on two parameters: μ-opioid receptor binding affinity and blood-brain barrier (BBB) permeability. Theoretical doses were very close to the drug doses at which mice showed place preference. Therefore, the CPP test is useful as a behavioral method for evaluating abuse-deterrent formulations of opioids mixed with an antagonist. The ratio of naloxone with opioids, at which mice did not show place preference, may be an effective index for developing abuse-deterrent formulations. Ratios may be calculated for other opioids based on μ-opioid receptor binding affinity and BBB permeability.\n"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"United States","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Analgesics, Opioid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Opioid-Related Disorders","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Abuse-Deterrent Formulations","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Naloxone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Narcotic Antagonists","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"An evaluation method for developing abuse-deterrent opioid formulations with agonist and antagonist combinations using conditioned place preference.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"An evaluation method for developing abuse-deterrent opioid formulations with agonist and antagonist combinations using conditioned place preference.","subitem_title_language":"en"}]},"item_type_id":"3","owner":"137","path":["297"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-03-13"},"publish_date":"2023-03-13","publish_status":"0","recid":"14755","relation_version_is_last":true,"title":["An evaluation method for developing abuse-deterrent opioid formulations with agonist and antagonist combinations using conditioned place preference."],"weko_creator_id":"137","weko_shared_id":-1},"updated":"2023-06-19T07:39:38.047164+00:00"}