@article{oai:gifu-pu.repo.nii.ac.jp:00008092,
 author = {河野, 通明 and コウノ, ミチアキ and KOHNO, MICHIAKI},
 journal = {岐阜藥科大學紀要, The annual proceedings of Gifu College of Pharmacy},
 month = {Jun},
 note = {P(論文), 種々の細胞増殖因子によってNa^+/H^+アンチポーターのCキナーゼによる活性化(その結果細胞質内pHが上昇する), あるいはリボゾームS6蛋白, 細胞質41K, 43K蛋白のリン酸化が急速に促進される。それらはいずれも増殖因子によってもたらされた細胞増殖促進情報の細胞核への伝達過程において不可欠の重要な役割を果たしていると考えられる。, Many growth-promoting agents have been shown to activate the amiloride-sensitive Na^+/ H^+ antiporter, leading to a rapid rise in cytoplasmic pH (pH_I) of 0.1-0.3 unit; it seems very likely that protein kinase C is involved in this activation process. Phosphorylation of cellular proteins such as ribosomal protein S6,and two 43000-Mr and two 41000-Mr proteins revealed by two-dimensional polyacrylamide-gel electrophoresis, has also been commonly observed after activation of quiescent fibroblasts with a variety of growth factors. The close correlation between mitogen action and the increased phosphorylation of these proteins is consistent with the notion that phosphorylation of such a common set of specific cellular proteins in limited number might be important for some early steps of the mitogenic-signalling pathway.},
 pages = {1--10},
 title = {<総説>細胞増殖促進と蛋白リン酸化反応},
 volume = {36},
 year = {1987}
}