{"created":"2023-06-19T07:23:27.987008+00:00","id":8095,"links":{},"metadata":{"_buckets":{"deposit":"54d9f75c-3c41-4a57-a0b2-07ae3f03e487"},"_deposit":{"created_by":5,"id":"8095","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"8095"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00008095","sets":["147:183"]},"author_link":["26261","25330","26258","26262","26259","26263","25298","24318","26260","23867","17747","22123","26264","24320","25300"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"41","bibliographicPageStart":"32","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"窪田, 種一"}],"nameIdentifiers":[{"nameIdentifier":"25300","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加納, 健司"}],"nameIdentifiers":[{"nameIdentifier":"25298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川田, 恵里子"}],"nameIdentifiers":[{"nameIdentifier":"26258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋爪, 博隆"}],"nameIdentifiers":[{"nameIdentifier":"26259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇野, 文二"}],"nameIdentifiers":[{"nameIdentifier":"17747","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"クボタ, タネカズ"}],"nameIdentifiers":[{"nameIdentifier":"26260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カノウ, ケンジ"}],"nameIdentifiers":[{"nameIdentifier":"25330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カワダ, エリコ"}],"nameIdentifiers":[{"nameIdentifier":"26261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハシヅメ, ハクタカ"}],"nameIdentifiers":[{"nameIdentifier":"26262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウノ, ブンジ"}],"nameIdentifiers":[{"nameIdentifier":"22123","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KUBOTA, TANEKAZU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KANO, KENJI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAWADA, ERIKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HASHIZUME, HAKUTAKA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"UNO, BUNJI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24318","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"化学結合型一逆相一高性能薄層クロマトグラフ法を用いて, フェノール類および安息酸類(1群), 塩基性の弱い芳香族アミン類(2群), それ以外の芳香族アミン類(3群), および酸解離不活性な置換基だけを有する芳香族化合物(4群)の疎水性パラメーターR_Mを測定した。固定相にはn-オクチルシリル化シリカ(Merck HPTLC RP-8 F_<254s>), 移動相としは通常50%(v/v)エタノール一水混合溶媒を用いた。R_M値は移動相の水成分のpHやイオン強度には依存しなかった。上記化合物のR_Mは各化合物群ごとで, 1-オクタノール-水系でのフラスコ振盪法で求めた分配係数指数logPと高い相関を有することがわかった。その相関における傾きはほぼ同じであったが, 切片は化合物群に依存していた。そこで置換基の種類(化合物群)に依存した3つの指示変数を導入して, すべての化合物に対して, R_Mと1ogPの間の良好な直線関係を得た。構造活性相聞の研究におけるR_M値の有用性についても考察した。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The hydrophobic parameter R_M values for phenol- and benzoic acid derivatives (group 1), aromatic amine derivatives with weak basicity (group 2), the other aromatic amine derivatives (group 3), and aromatic compounds having no dissociation active center (group 4) were determined using a chemically modified reversed-phase high-performance thin-layer chromatography. Octylsilylated silicagel plate (Merck HPTLC RP-8 F_<254s>) and 50% (v/v) aqueous ethanol were usually served as stationary and mobile phases, respectively. The R_M values thus obtained were independent of the pH and the ionic strength of the aqueous component in the mobile phase. Also, the R_M values were correlated significantly to the logP values for compounds in each group mentioned above (P : partition coefficient determined by shake-flask method on 1-Octanol-water system). Although the slopes of the regression equations are almost independent of the chemical structures without regard to the said classification of samples, the intercepts at the ordinate depend on the groups. However, a good correlation between R_M and logP of all the substances used here was obtained by introducing the three indicator variables representing the characteristics of structures pertaining to each group. The utility of R_M Values in the study of structure-activity relationship has discussed.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University/Department of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University/Department of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University:(Present address) Research Laboratory of Nikkaki Co., Ltd./Department of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University:(Present address) Department of Phamaceutics, National Nagoya Hospital/Department of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学/岐阜薬科大学/岐阜薬科大学:(現)株式会社日科機研究所/岐阜薬科大学:(現)国立名古屋病院薬剤部/岐阜薬科大学"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1987-06-30"}],"displaytype":"detail","filename":"KJ00000072021.pdf","filesize":[{"value":"749.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/8095/files/KJ00000072021.pdf"},"version_id":"f80f08f7-5137-4d9c-ae67-07909658d60c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<一般論文>化学結合型-逆相-高性能薄層クロマトグラフ法による分配係数の新測定法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<一般論文>化学結合型-逆相-高性能薄層クロマトグラフ法による分配係数の新測定法"},{"subitem_title":"<Regular Article>New Method for Determining True Partition Coefficients by the Technique of Chemically Modified Reserved-Phase High-Performance Thin-Layer Chromatography","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["183"],"pubdate":{"attribute_name":"公開日","attribute_value":"1987-06-30"},"publish_date":"1987-06-30","publish_status":"0","recid":"8095","relation_version_is_last":true,"title":["<一般論文>化学結合型-逆相-高性能薄層クロマトグラフ法による分配係数の新測定法"],"weko_creator_id":"5","weko_shared_id":5},"updated":"2023-06-19T08:07:10.994016+00:00"}