{"created":"2023-06-19T07:23:43.903836+00:00","id":8470,"links":{},"metadata":{"_buckets":{"deposit":"2fc7ea37-a248-4785-9615-6d258f00b511"},"_deposit":{"created_by":5,"id":"8470","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"8470"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00008470","sets":["147:186"]},"author_link":["24196","25629","25632","24195","25639","25634","20916","25636","25633","25631","25637","20915","25630","25635","25638"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"43","bibliographicPageStart":"29","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 巳喜男"}],"nameIdentifiers":[{"nameIdentifier":"20915","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"広瀬, 美香"}],"nameIdentifiers":[{"nameIdentifier":"25629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甲斐, 茂男"}],"nameIdentifiers":[{"nameIdentifier":"25630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堀, 松浩"}],"nameIdentifiers":[{"nameIdentifier":"25631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林, 尊宏"}],"nameIdentifiers":[{"nameIdentifier":"25632","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"スズキ, ミキオ"}],"nameIdentifiers":[{"nameIdentifier":"20916","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヒロセ, ミカ"}],"nameIdentifiers":[{"nameIdentifier":"25633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カイ, シゲオ"}],"nameIdentifiers":[{"nameIdentifier":"25634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ホリ, マツヒロ"}],"nameIdentifiers":[{"nameIdentifier":"25635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハヤシ, タカヒロ"}],"nameIdentifiers":[{"nameIdentifier":"25636","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SUZUKI, MIKIO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIROSE, MIKA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"25637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAI, SHIGEO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HORI, MATSUHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"25638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAYASHI, TAKAHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"25639","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"近年, 癌の光力学療法(PDT)が注目され, 精力的な研究が広範に進められている。現在, PDTの臨床試験に用いられている光増感剤としては, ヘマトポルフィリン誘導体(Hpd)が挙げられる。しかしながら, このHpdは, 高い組織透過性を有する600nm以上の可視光に対して弱い吸収を示すにとどまり, さらにHpd中の活性成分が腫瘍組織に取り込まれる割合は, 正常組織に比べてけた外れに大きいわけではない。したがって, より効果的なPDTを実施するにあたり, 適用される光増感剤としては, 組織透過性の高い赤色光領域に強い吸収を持ち, 腫瘍組織に対して高い選択性および親和性を具備するものが望まれる。このような理由で, 最近, 多種多様な新しい光増感剤が登場してきた。なかでも, メソ置換ポルフィリン, クロリン誘導体, バクテリオクロリンおよびフタロシアニンが, PDTにおける第二世代光増感剤として注目を集めている。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"There is currently worldwide activity in the development of a photodynamic therapy (PDT) for cancer. The sensitizer currently used in clinical trials of PDT for cancer consists of a mixture of hematoporphyrin derivatives (Hpd). Hpd, however, absorbs only weakly above 600nm where light exhibits the deepest penetration into tissues. Furthermore, the uptake by the tumour of the active component in Hpd is only marginally higher than that by most normal tissues. Thus it has been evident for some time that the effectiveness of PDT could be enhanced by the use of photosensitizers that absorb more strongly towards the red end of the light spectrum and are more selectively retained by neoplastic tissues. For these reasons, several new classes of photosensitizers for PDT have been suggested over the past few years. Among them, substituted porphyrins, chlorin analogs, bacteriochlorins, and phtalocyanines have received increasing attention as a second- gereration photosensitizer in PDT.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of General Chemistry, Gifu Pharmaceutical University/Department of General Chemistry, Gifu Pharmaceutical University/Department of General Chemistry, Gifu Pharmaceutical University/Department of General Chemistry, Gifu Pharmaceutical University/Department of General Chemistry, Gifu Pharmaceutical University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学一般化学研究室/岐阜薬科大学一般化学研究室/岐阜薬科大学一般化学研究室/岐阜薬科大学一般化学研究室/岐阜薬科大学一般化学研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1990-06-30"}],"displaytype":"detail","filename":"KJ00000072396.pdf","filesize":[{"value":"984.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/8470/files/KJ00000072396.pdf"},"version_id":"2bd7a7b4-6a1b-477d-9f97-15f4b0e9c368"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>癌光力学療法におけるポルフィリン系光増感剤","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>癌光力学療法におけるポルフィリン系光増感剤"},{"subitem_title":"<Review>Porphyrin Analogs as Photosensitizers in a Photodynamic Cancer Therapy","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["186"],"pubdate":{"attribute_name":"公開日","attribute_value":"1990-06-30"},"publish_date":"1990-06-30","publish_status":"0","recid":"8470","relation_version_is_last":true,"title":["<総説>癌光力学療法におけるポルフィリン系光増感剤"],"weko_creator_id":"5","weko_shared_id":5},"updated":"2023-06-19T08:15:29.557896+00:00"}