The Hiyama cross-coupling reaction, a palladium-catalyzed carbon–carbon bond formation between organosilanes and
organohalides or their equivalents, has been popularized as a useful synthetic method to construct unsymmetrical biphenyls as
structural components of various functional materials. The use of organosilanes as organometallic compounds, which was initially
explored by Hiyama, is one of the most attractive approaches, since organosilanes are easy to handle and environmentally friendly
due to their air-stability and low toxicity. Hiyama coupling has generally been achieved by the combined use of a homogeneous
palladium catalyst and a phosphine ligand. Recently, the development of heterogeneously palladium-catalyzed cross-coupling
reactions has attracted significant attention from both environmental and economical points of view, since the catalysts can be readily
recovered from the reaction mixture. Efficient methods are demonstrated for the palladium on carbon (Pd/C)-catalyzed Hiyama
cross-coupling reactions and the first ligand-free Pd/C-catalyzed Hiyama cross-coupling reaction between a variety of aryl halides
and aryltriethoxysilanes.
雑誌書誌ID
AA1258935X
雑誌名
岐阜薬科大学紀要
雑誌名(英)
The annual proceedings of Gifu Pharmaceutical University
パラジウム炭素を触媒とした檜山クロスカップリング反応
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パラジウム炭素を触媒とした檜山クロスカップリング反応
(940.25KB)
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