{"_buckets": {"deposit": "c8724565-7c13-4a64-8a93-29d293914b48"}, "_deposit": {"created_by": 5, "id": "12783", "owners": [5], "pid": {"revision_id": 0, "type": "depid", "value": "12783"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00012783", "sets": ["201"]}, "author_link": ["17807", "17808", "17806"], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-06-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "11", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "54", "bibliographic_titles": [{"bibliographic_title": "岐阜藥科大學紀要"}, {"bibliographic_title": "The annual proceedings of Gifu College of Pharmacy", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "川島, 嘉明"}], "nameIdentifiers": [{"nameIdentifier": "17806", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_7": {"attribute_name": "著者名よみ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "カワシマ, ヨシアキ"}], "nameIdentifiers": [{"nameIdentifier": "17807", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_8": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "KAWASHIMA, Yoshiaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17808", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "初めに薬物キャリアーの微粒化(ナノ化)により薬物送達システムの機能が向上する理由と、その機能を発揮させるための製剤化法として、コンポジットシステムが必用な理由を述べる。微粒子DDSとして、生体内分解性高分子ナノスフェアの調製法を化学的方法と物理化学的方法について概説し、著者等が開発した、高分子球形晶析法についてその原理と乳酸グリコール酸共重体(PLGA)ナノスフェアの調製法への応用例を紹介する。粒子の物理化学的コンポジット化法を概観し、著者等の噴霧乾燥法による調製例を紹介する。コンポジット化ナノ粒子DDSの開発例として、経肺投与型粉末吸入システム(DPI)の設計を取り上げる。具体例として難溶性抗喘息薬のナノ晶析と凍結乾燥法によるナノコンポジット粒子DPIの設計とモルモットヘの経気管支投与による薬理作用の向上について述べる。インスリンのDPIシステムとして、インスリン封入PLGAナノスフェアを噴霧乾燥流動層法によりコンポジットとする方法や、凍結乾燥PLGAナノスフェアをドライパウダー(オーダードミキシング)複合化装置でコンポジット化する方法について説明し、これらをラットヘの経肺投与により血糖値降下作用が静脈注射と比較して有意に増大しその効果が持続化できたことについて述べる。現在、理想的な治療システムのための種々のナノテクDDSが開発されつつある。これらを製剤化するための新しいコンポジット化法の開発が急務である。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Improving the function of a drug delivery system (DDS) with a micronized (nanosized) drug carrier and the composition of DDS required for developing them to a practical dosage form are explained. Physicochemical and chemical preparation methods of biodegradable polymeric nanospheres are described as a micronized particulate DDS. The principle of the polymeric spherical crystallization technique developed by us and their applications to prepare DL-lactide/glycolide copolymer (PLGA) nanosphere are introduced. Physicochemical methods for the preparation of a particulate composite are overviewed and the spray drying method developed by us is referred as a practical example. Development of a dry powder inhalation system with nanocomposite particulate DDS is described. The pharmacological action of a poorly soluble anti-asthmatic drug via pulmonary administration to guinea pig was improved with nanocomposite DPI prepared by nanocrystallization and freeze drying method. Insulin encapsulated PLGA nanosphere composite was prepared by a spray drying fluidized bed system and a dry powder composing (ordered mixing) system, which reduced significantly the blood glucose level with prolonged action administered intratrachealy to rat compared to intravenous injection. Various updated DDS have been developed by using nanotechnology to find an ideal therapeutic system, which requires a novel composite system to develop them as practical dosage form.", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00053514", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Laboratory of Pharmaceutical Enginering, Gifu Pharmaceutical University"}]}, "item_1_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "総設"}]}, "item_1_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Review"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岐阜薬科大学製剤学教室"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2005-06-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004170370.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"url": "https://gifu-pu.repo.nii.ac.jp/record/12783/files/KJ00004170370.pdf"}, "version_id": "3d7ee30d-5348-43b2-aa75-63328311ba17"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "コンポジットナノ粒子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PLGAナノスフェア", "subitem_subject_scheme": "Other"}, {"subitem_subject": "高分子球形晶析法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "吸入投与型インスリンDDS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "噴霧乾燥", "subitem_subject_scheme": "Other"}, {"subitem_subject": "流動層法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ドライパウダー複合化法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nanocomposite particulate system", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PLGA nanosphere", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "polymeric spherical crystallization method", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "insulin inhalatoin DDS", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "spray drying fluidized bed method", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dry powder composing system", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "コンポジット化ナノ粒子薬物送達システムの設計", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "コンポジット化ナノ粒子薬物送達システムの設計"}, {"subitem_title": "Design of a Nanocomposite Praticulate Drug Delivery System", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "5", "path": ["201"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/12783", "pubdate": {"attribute_name": "公開日", "attribute_value": "2005-06-30"}, "publish_date": "2005-06-30", "publish_status": "0", "recid": "12783", "relation": {}, "relation_version_is_last": true, "title": ["コンポジット化ナノ粒子薬物送達システムの設計"], "weko_shared_id": -1}