{"_buckets": {"deposit": "112af1b4-ad94-4248-a9db-0f8eb17b86f9"}, "_deposit": {"created_by": 5, "id": "12848", "owners": [5], "pid": {"revision_id": 0, "type": "depid", "value": "12848"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00012848", "sets": ["204"]}, "author_link": ["17895", "17894", "17896"], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-06-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "64", "bibliographicPageStart": "55", "bibliographicVolumeNumber": "57", "bibliographic_titles": [{"bibliographic_title": "岐阜藥科大學紀要"}, {"bibliographic_title": "The annual proceedings of Gifu College of Pharmacy", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "鈴木, 猛志"}], "nameIdentifiers": [{"nameIdentifier": "17894", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_7": {"attribute_name": "著者名よみ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "スズキ, タケシ"}], "nameIdentifiers": [{"nameIdentifier": "17895", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_8": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SUZUKI, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17896", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "糖尿病性神経障害の発症進展機序解明の一端として、末梢神経機能維持に重要な役割を果たすシュワン細胞に着目し、ポリオール代謝経路亢進および終末糖化産物(AGEs)の細胞機能に対する影響を検討した。ラット末梢神経から単離培養したシュワン細胞において高濃度グルコース下でのポリオール代謝経路の亢進が確認され、その亢進に伴い、ニューロトロフィン-3(NT-3)誘導性の神経成長因子(NGF)産生能が低下することが明らかになった。また、その低下にはポリオール代謝経路亢進に依存した酸化ストレスの増大の関与が示唆された。つぎに、グリセルアルデヒドおよびグリコールアルデヒドAGEsがアポトーシスおよび炎症性サイトカイン産生を誘導することを明らかにした。さらに、不死化マウスシュワン細胞IMS32を用い、高濃度グルコース下で網羅的遺伝子発現変化について検討した結果、ポリオール代謝経路亢進依存的に、毒性アルデヒドの解毒に関わるアルデヒド還元酵素遺伝子の発現が低下するものと考えられる。以上の成績から、糖尿病下の末梢神経では高血糖に起因したポリオール代謝経路の完遂とAGEsによるシュワン細胞障害が誘発され、糖尿病性神経障害が発症進展することが示唆された。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "To elucidate the mechanisms of the development of diabetic neuropathy, we investigated the involvement of increased polyol pathway flux and advanced glycation end-products (AGEs) on the dysfunction in Schwann cells which play an important role in the peripheral nervous systems. In the cultured Schwann cells isolated from rat sciatic nerves, neurotrophin-3 (NT-3)-induced nerve growth factor (NGF) production was suppressed under high glucose conditions due to enhanced oxidative stress linked to the acceleration of the polyol pathway. Glyceraldehyde- and glycolaldehyde- derived AGEs induced apoptosis and production of inflammatory cytokines. Moreover with DNA microarray and northern blot analysis in the immortalized mouse Schwann cell line IMS32, the reduction in mRNA expression of aldehyde reductase related to detoxification of toxic aldehydes was observed through the increase in the polyol pathway flux. Taken together, Schwann cell injury caused by polyol pathway flux acceleration and directive affect of AGEs seems to play a key role in the impairment of nerve function in the peripheral nerve of diabetic patients.", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00053514", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd."}]}, "item_1_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "総説"}]}, "item_1_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Review"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "株式会社三和化学研究所製薬研究所"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2008-06-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00005059083.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"url": "https://gifu-pu.repo.nii.ac.jp/record/12848/files/KJ00005059083.pdf"}, "version_id": "7cdf6a81-69a3-44c1-bced-9ad1fe6710ef"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "糖尿病性神経障害", "subitem_subject_scheme": "Other"}, {"subitem_subject": "シュワン細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ポリオール代謝経路", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アルドース還元酵素", "subitem_subject_scheme": "Other"}, {"subitem_subject": "終末糖化産物", "subitem_subject_scheme": "Other"}, {"subitem_subject": "酸化ストレス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "神経成長因子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アルデヒド還元酵素", "subitem_subject_scheme": "Other"}, {"subitem_subject": "diabetic neuropathy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Schwann cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "polyol pathway", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "aldose reductase", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "advanced glycation end-products", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oxidative stress", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nerve growth factor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "aldehyde reductase", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "糖尿病性神経障害におけるシュワン細胞機能異常に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "糖尿病性神経障害におけるシュワン細胞機能異常に関する研究"}, {"subitem_title": "Impaired Function of Schwann Cells in Diabetic Neuropathy", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "5", "path": ["204"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/12848", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-06-30"}, "publish_date": "2008-06-30", "publish_status": "0", "recid": "12848", "relation": {}, "relation_version_is_last": true, "title": ["糖尿病性神経障害におけるシュワン細胞機能異常に関する研究"], "weko_shared_id": -1}