{"_buckets": {"deposit": "d1ca1ad3-d733-4dfe-9a0a-59588ba2b2aa"}, "_deposit": {"created_by": 4, "id": "12913", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "12913"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00012913", "sets": ["215"]}, "author_link": ["17943", "17944", "17954"], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-06-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "7", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "58", "bibliographic_titles": [{"bibliographic_title": "岐阜薬科大学紀要"}, {"bibliographic_title": "The annual proceedings of Gifu Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "永井, 博弌"}], "nameIdentifiers": [{"nameIdentifier": "17943", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_7": {"attribute_name": "著者名よみ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ナガイ, ヒロイチ"}], "nameIdentifiers": [{"nameIdentifier": "17954", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_8": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NAGAI, Hiroichi ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17944", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "気管支喘息は全世界で約３億人、日本では約４５０万人の患者がいると言われ、一般に良く知られた疾患である。また、近年の医療に関する学問および技術の著しい進歩により、多くの慢性疾患には治療ガイドラインが導入され、治療の標準化が進みつつある。気管支喘息についても国際的にはGINAをはじめとする国際的な研究機関や機構から、また国内では日本アレルギー学会が中心となって治療ガイドラインが提案されている。このような背景から、気管支喘息の治療は大きく進歩したが、個人の持つ体質などによる個体差や病勢によって薬物の治療効果にはばらつきがあり、いまだ充分なものとは言い難い。そこで、近年、種々のバイオマーカーを指標に個体差を解消して、個人個人に適した治療を行おうとするパーソナル医療あるいはテーラーメイド医療が注目されている。また、治療を効果的に行なうには疾患の病態を正確に把握することが必要であり、病態の解明が治療薬の選択の大きなカギとなる。このようなことから本総説では気管支喘息の病態とパーソナル医療の現状と将来への展望について概説した。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Bronchial asthma is a chronic inflammatory disease of the airway characterized by intermittent bronchoconstriction and an increase in airway edema and mucus secretion. There is considerable variation in the pathophysiologic features apparent among different patients with asthma. Many potential reasons are considered for this variation. Despite remarkable advances in diagnosis and treatment, bronchial asthma is still an intractable disease. The goal of pharmacotherapy is to retain normal activity levels as a healthy person. According to guidelines, pharmacotherapy is initiated to establish prompt control then slowly stepped-down to minimize the risk of adverse effects without sacrificing efficacy. Treatment guidelines have led to improvement in overall care of asthma, though some patients have not responded to recommended drug therapy. Many reasons, such as severity of disease, concurrent illness, environmental exposure, medication noncompliance and inter-patient genetic variability in response to asthma therapy, may play a factor in treatment efficacy. Genetic factors, including polymorphism in a gene or random DNA position or in a series of associated alleles, are important factors to determine heterogeneous responses to pharmacological treatment. In this manuscript, recent data concerning drug therapy tailored to an asthmatic patient\u0027s genotype will be reviewed.", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1258935X", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Gifu Pharmaceutical University"}]}, "item_1_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "総説"}]}, "item_1_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Review"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岐阜薬科大学"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2014-07-09"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "喘息治療薬のファーマコゲノミクス.pdf", "filesize": [{"value": "570.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 570000.0, "url": {"label": "喘息治療薬のファーマコゲノミクス", "url": "https://gifu-pu.repo.nii.ac.jp/record/12913/files/喘息治療薬のファーマコゲノミクス.pdf"}, "version_id": "c80d779d-4dcd-4874-97db-92d176c1c8ec"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "気管支喘息", "subitem_subject_scheme": "Other"}, {"subitem_subject": "パーソナル医療", "subitem_subject_scheme": "Other"}, {"subitem_subject": "治療ガイドライン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "バイオマーカー", "subitem_subject_scheme": "Other"}, {"subitem_subject": "喘息治療薬", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bronchial asthma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "goal of pharmacotherapy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "treatment guideline", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "polymorphism in a gene", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "喘息治療薬のファーマコゲノミクス", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "喘息治療薬のファーマコゲノミクス"}, {"subitem_title": "Pharmacogenomics in the Treatment of Asthma", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "4", "path": ["215"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/12913", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-06-27"}, "publish_date": "2014-06-27", "publish_status": "0", "recid": "12913", "relation": {}, "relation_version_is_last": true, "title": ["喘息治療薬のファーマコゲノミクス"], "weko_shared_id": -1}