{"_buckets": {"deposit": "40fd99eb-df09-4c98-b321-5f8858cecbae"}, "_deposit": {"created_by": 4, "id": "12914", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "12914"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00012914", "sets": ["215"]}, "author_link": ["17946", "17945", "17949", "17950", "17948", "17947"], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-06-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "18", "bibliographicPageStart": "9", "bibliographicVolumeNumber": "58", "bibliographic_titles": [{"bibliographic_title": "岐阜薬科大学紀要"}, {"bibliographic_title": "The annual proceedings of Gifu Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "瀬尾, 誠"}], "nameIdentifiers": [{"nameIdentifier": "17945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "永瀬, 久光"}], "nameIdentifiers": [{"nameIdentifier": "17946", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_7": {"attribute_name": "著者名よみ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "セオ, マコト"}], "nameIdentifiers": [{"nameIdentifier": "17949", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ナガセ, ヒサミツ"}], "nameIdentifiers": [{"nameIdentifier": "17950", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_8": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SEO, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17947", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAGASE, Hisamitsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17948", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "アレルギー疾患発症・重症化の要因として、ディーゼル排気ガス粒子やホルムアルデヒドなど様々な環境因子の関与が報告されている。本研究では、大気および水質汚染物質である有機塩素系溶剤の中でもトリクロロエチレン(TCE) およびテトラクロロエチレン (PCE) が、肥満細胞からのヒスタミン遊離および炎症性サイトカイン産生を顕著に亢進することを見出した。また水道水質基準値レベルの TCE および PCE をラットに飲水摂取させたところ、肥満細胞のヒスタミン遊離反応亢進と血管周辺への局所的集積を介して I 型アレルギー反応を亢進すると考えられた。また、両化合物は肥満細胞や単核球からの IL-4 や TNF-α 産生を亢進して後期炎症反応の惹起を助長し、さらに Th1/Th2 サイトカインバランスを Th2 側に偏らせることで、アレルギー反応を亢進させているものと考えられた。本研究で得られた知見は、地下水汚染物質として問題となっている有機塩素系溶剤の水道水質基準レベルの摂取がアレルギー反応増悪化・重症化に関与することを示唆するもので、水質管理における衛生学的な見地からも意義深いものである。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Many reports show that various environmental pollutants, such as diesel exhaust particles and formaldehyde, are closely related to increases in allergic diseases. In this study, it was found that certain chlorinated organic solvents, in particular trichloroethylene (TCE) and tetrachloroethylene (PCE), which are major air and water pollutants, significantly enhanced histamine release and inflammatory cytokine production from antigen-stimulated mast cells. TCE and/or PCE ingestion from drinking water increased the accumulation of mast cells around the vessel in the skin and histamine release from peritoneal mast cells. These results suggest that low concentration of TCE and PCE leads to acceleration of Type I allergic reaction. TCE and PCE showed increased interleukin (IL)-4 and tumor necrosis factor (TNF)-α production from mast cells and leukocytes which promoted initiation of late-inflammatory responses. TCE and PCE ingestion from drinking water also increased IL-4 production and decreased IFN-γ production. These results suggested that TCE and PCE ingestion aggravate allergic responses via Th1/Th2 cytokine imbalance. Our results suggested that the low concentrations of chlorinated organic solvents, even at Japanese government environmental standards for water and Japanese government drinking water quality guidelines, lead to the initiation and aggravation of allergic reactions. These significant findings are important in hygienic water quality management.", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1258935X", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Laboratory of Hygienics, Gifu Pharmaceutical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Biochemistry, Faculty of Medicine, Saitama Medical University"}]}, "item_1_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "総説"}]}, "item_1_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Review"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岐阜薬科大学衛生学研究室"}, {"subitem_text_value": "埼玉医科大学医学部生化学研究室"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2014-07-09"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "有機塩素系溶剤によるアレルギー反応増悪化に関する研究.pdf", "filesize": [{"value": "968.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 968700.0, "url": {"label": "有機塩素系溶剤によるアレルギー反応増悪化に関する研究", "url": "https://gifu-pu.repo.nii.ac.jp/record/12914/files/有機塩素系溶剤によるアレルギー反応増悪化に関する研究.pdf"}, "version_id": "830c1929-34b4-4a88-b680-84528afaab6c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "トリクロロエチレン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "テトラクロロエチレン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "肥満細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ヒスタミン遊離", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Th1/Th2 サイトカインバランス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "trichloroethylene", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tetrachloroethylene", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mast cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histamine release", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Th1/Th2 cytokine balance", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "有機塩素系溶剤によるアレルギー反応増悪化に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "有機塩素系溶剤によるアレルギー反応増悪化に関する研究"}, {"subitem_title": "Enhancing Effect of Chlorinated Organic Solvents on Allergic Reactions", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "4", "path": ["215"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/12914", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-06-27"}, "publish_date": "2014-06-27", "publish_status": "0", "recid": "12914", "relation": {}, "relation_version_is_last": true, "title": ["有機塩素系溶剤によるアレルギー反応増悪化に関する研究"], "weko_shared_id": -1}