{"_buckets": {"deposit": "db83d3a3-90a1-4adf-8915-8b14af8fed9a"}, "_deposit": {"created_by": 4, "id": "13001", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "13001"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00013001", "sets": ["223"]}, "author_link": ["18152", "18153", "18154", "18155", "18157", "18156"], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-06-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "20", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "64", "bibliographic_titles": [{"bibliographic_title": "岐阜薬科大学紀要"}, {"bibliographic_title": "The annual proceedings of Gifu Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "宇佐美, 英績"}], "nameIdentifiers": [{"nameIdentifier": "18152", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "寺町, ひとみ"}], "nameIdentifiers": [{"nameIdentifier": "18153", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_7": {"attribute_name": "著者名よみ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ウサミ, エイセキ"}], "nameIdentifiers": [{"nameIdentifier": "18154", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "テラマチ, ヒトミ"}], "nameIdentifiers": [{"nameIdentifier": "18155", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_8": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "USAMI, Eiseki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "18156", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TERAMACHI, Hitomi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "18157", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "造血器腫瘍患者への化学療法は、強力で副作用の出現率も高い。副作用コントロールの善し悪しが治療の継続性、\n相対的治療強度（relative dose intensity： RDI）あるいはquality of life の低下に繋がる。まず筆者らは、非ホジキンリンパ\n腫患者に対する通常量化学療法後のステロイド離脱症状頻度とステロイド漸減療法による症状軽減効果の検討を行った。\nその結果、ステロイド漸減療法は安全で有効率も高く症状の改善が期待できた。特に高齢者の場合は、ステロイド離脱症\n状が強ければ積極的に早い段階から行う必要があると考えられた。次に、RDI に関与する重篤な感染症の1 つとして、非\nホジキンリンパ腫患者における帯状疱疹の出現の解析を行った。帯状疱疹発症に関する有意な危険因子として、自己末梢\n血幹細胞移植後、再発患者、総治療回数10 回以上、使用レジメン2 種類以上が見出された。帯状疱疹発症の危険性があ\nる患者へは、少量の抗ウイルス薬の予防投与を考慮すべきであり、他の感染同様に注意深く経過観察を行う必要があるこ\nとを明らかにした。さらに、造血器腫瘍領域において真菌感染の第一選択薬に推奨され汎用されているLiposomal\n-Amphotericin B 投与による低カリウム血症と適正なカリウム補正に関する検討を行った。Grade3 以上の低カリウム血症\nは53.8%出現し、血清カリウム値が2.83 mEq/L を下回る前にカリウム補正を開始することが必要であり、血清カリウム\n値が低下しすぎない早期から補正を行うことが電解質異常の重篤化を予防するために重要であることを明らかにした。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "The chemotherapy treatment of hematological patients is associated with an increased risk of adverse events because of the\nintensity of the treatment. Adverse event management leads to continuous treatments, a relative dose intensity, and quality of life.\nTherefore, we evaluated the prevalence of steroid withdrawal syndrome (SWS) to assess the relevance of steroid tapering in\nnon-Hodgkin lymphoma (NHL) patients who received general NHL chemotherapy. We conclude that steroid tapering is a safe and\neffective treatment method. If the patient has serious symptoms of SWS, steroid tapering should be introduced aggressively and early,\nespecially in elderly patients. We then examined the frequency of herpes zoster as a fatal infection in NHL patients. Significant risk\nfactors for the development of herpes zoster were post-autologous peripheral blood stem cell transplantation, relapse, 10 or more total\ntreatments, and the use of two or more regimens. We recommend that it is necessary to consider the prophylactic use of low-dose\nanti-viral drugs in patients who have a higher risk of herpes zoster. We also recommend further observation of other opportunistic\ninfections associated with chemotherapy usage. In addition, we examined the appropriate potassium supplementation conditions to\ntreat hypokalemia induced by liposomal-amphotericin B (L-AMB), which is recommended as a first-line anti-fungal drug for\nhematological patients. Hypokalemia greater than grade 3 was exhibited by 53.8% patients. It is necessary to begin potassium\nsupplementation prior to the reduction of serum potassium levels to \u003c2.83 mEq/l. Potassium supplementation at an early stage of\nL-AMB treatment is important to prevent severe electrolyte abnormalities.", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1258935X", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pharmacy, Ogaki Municipal Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University"}]}, "item_1_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "総説"}]}, "item_1_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Review"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "大垣市民病院薬剤部"}, {"subitem_text_value": "岐阜薬科大学実践薬学大講座病院薬学研究室"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-12-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "造血器腫瘍患者への化学療法支援に対する臨床薬学的研究.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "造血器腫瘍患者への化学療法支援に対する臨床薬学的研究", "url": "https://gifu-pu.repo.nii.ac.jp/record/13001/files/造血器腫瘍患者への化学療法支援に対する臨床薬学的研究.pdf"}, "version_id": "97a6d9a2-d8b4-4d59-97c3-98150fe84d56"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "造血器腫瘍患者", "subitem_subject_scheme": "Other"}, {"subitem_subject": "化学療法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ステロイド離脱症候群", "subitem_subject_scheme": "Other"}, {"subitem_subject": "帯状疱疹", "subitem_subject_scheme": "Other"}, {"subitem_subject": "低カリウム血症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hematological Patient", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chemotherapy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Steroid Withdrawal Syndrome", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Herpes Zoster", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hypokalemia", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "造血器腫瘍患者への化学療法支援に対する臨床薬学的研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "造血器腫瘍患者への化学療法支援に対する臨床薬学的研究"}, {"subitem_title": "Evaluation of Clinical Pharmaceutical Support Care in Hematological Patients", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "4", "path": ["223"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/13001", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-12-07"}, "publish_date": "2015-12-07", "publish_status": "0", "recid": "13001", "relation": {}, "relation_version_is_last": true, "title": ["造血器腫瘍患者への化学療法支援に対する臨床薬学的研究"], "weko_shared_id": -1}