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  1. 教員研究業績
  2. 製剤学研究室
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Effects of cationic liposomes with stearylamine against virus infection.

https://gifu-pu.repo.nii.ac.jp/records/13105
https://gifu-pu.repo.nii.ac.jp/records/13105
46829c78-b848-41c6-b37a-7fa5a71ca84d
Item type 研究室原著論文(1)
公開日 2018-04-03
タイトル
タイトル Effects of cationic liposomes with stearylamine against virus infection.
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 Liposome
キーワード
主題Scheme Other
主題 Stearylamine
キーワード
主題Scheme Other
主題 Baculovirus
キーワード
主題Scheme Other
主題 HSV-1
キーワード
主題Scheme Other
主題 A549
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
抄録
値 In this study, we demonstrated that cationic liposomes with incorporated stearylamine (SA) inhibit viral infectivity without preloaded active pharmaceutical ingredients. Specifically, we correlated physiochemical properties of liposomes, such as zeta potentials and particle sizes, with virus infectivity using the BacMam™ reagent, which is based on recombinant baculovirus (BV). Compared with neutral or negatively-charged liposomes, SA liposomes suppressed BV infectivity in several mammalian cell lines, including A549 cells. SA liposomes inhibited BV infection over 80% by optimizing the liposomal concentration and exposure time with cells. Moreover, these antiviral SA liposomes were not cytotoxic, and reducing the embedded cholesterol contents intensified the antiviral effects and simultaneously increased the binding of SA liposomes to the cell membranes. These data indicate that binding of SA liposomes to cell membranes may block virus entry. Finally, we also demonstrated the antiviral effects of SA liposomes on herpes simplex virus type 1 in A549 cells, and showed comparable efficacy to that of the antiviral drug acyclovir.
書誌情報 en : International journal of pharmaceutics

巻 543, 号 1-2, p. 311-317, 発行日 2018-05-30
DOI
値 10.1016/j.ijpharm.2018.04.001
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Cite as

2018, Effects of cationic liposomes with stearylamine against virus infection.: 311–317 p.

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