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Evaluation of liposomal behavior in the gastrointestinal tract after oral administration using real-time in vivo imaging.
https://gifu-pu.repo.nii.ac.jp/records/13106
https://gifu-pu.repo.nii.ac.jp/records/13106e6bb069c-d9cf-4218-9c96-c3bcc4215c12
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-11-23 | |||||
| タイトル | ||||||
| タイトル | Evaluation of liposomal behavior in the gastrointestinal tract after oral administration using real-time in vivo imaging. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | n vivo imaging | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oral administration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | indocyanine green | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | liposome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chitosan | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Liposomes are regarded as promising drug carriers for enhancing the pharmacological effects of poorly absorbed drugs, such as peptides, following oral administration. Liposomal surface modifications by mucoadhesive polymers could improve drug absorption through interactions with the mucus layer. The main purpose of this study was to establish a method of monitoring the behavior of liposomes within the body after oral administration, particularly in the gastrointestinal (GI) tract, using a real-time in vivo imaging system (IVIS) to elucidate the behavior of surface-modified liposomes. Indocyanine green (ICG) was used as a near-infrared dye to label chitosan (CS) or glycol CS (GCS)-modified liposomes, and to observe the dynamic behavior of the liposomes in rats by noninvasive IVIS after oral administration. First, we validated IVIS results of the rat abdomens by comparing them to quantitative measurements of ICG fluorescence intensity in tissue homogenates. Nano-sized small unilamellar vesicles were retained longer than micro-sized multilamellar vesicles in the GI tract. Furthermore, surface-modified liposomes showed longer-term retention in the GI tract than unmodified liposomes in fasted rats. Moreover, surface modification by CS or GCS effectively prevented the excretion of liposomes from the GI tract and prolonged retention in fed rats. | |||||
| 書誌情報 |
en : Drug development and industrial pharmacy 巻 44, 号 4, p. 608-614, 発行日 2017-11-30 |
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| DOI | ||||||
| 値 | 10.1080/03639045.2017.1405972 | |||||
