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  1. 教員研究業績
  2. 製剤学研究室
  3. 原著論文

Evaluation of liposomal behavior in the gastrointestinal tract after oral administration using real-time in vivo imaging.

https://gifu-pu.repo.nii.ac.jp/records/13106
https://gifu-pu.repo.nii.ac.jp/records/13106
e6bb069c-d9cf-4218-9c96-c3bcc4215c12
Item type 研究室原著論文(1)
公開日 2017-11-23
タイトル
タイトル Evaluation of liposomal behavior in the gastrointestinal tract after oral administration using real-time in vivo imaging.
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 n vivo imaging
キーワード
主題Scheme Other
主題 oral administration
キーワード
主題Scheme Other
主題 indocyanine green
キーワード
主題Scheme Other
主題 liposome
キーワード
主題Scheme Other
主題 chitosan
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
抄録
値 Liposomes are regarded as promising drug carriers for enhancing the pharmacological effects of poorly absorbed drugs, such as peptides, following oral administration. Liposomal surface modifications by mucoadhesive polymers could improve drug absorption through interactions with the mucus layer. The main purpose of this study was to establish a method of monitoring the behavior of liposomes within the body after oral administration, particularly in the gastrointestinal (GI) tract, using a real-time in vivo imaging system (IVIS) to elucidate the behavior of surface-modified liposomes. Indocyanine green (ICG) was used as a near-infrared dye to label chitosan (CS) or glycol CS (GCS)-modified liposomes, and to observe the dynamic behavior of the liposomes in rats by noninvasive IVIS after oral administration. First, we validated IVIS results of the rat abdomens by comparing them to quantitative measurements of ICG fluorescence intensity in tissue homogenates. Nano-sized small unilamellar vesicles were retained longer than micro-sized multilamellar vesicles in the GI tract. Furthermore, surface-modified liposomes showed longer-term retention in the GI tract than unmodified liposomes in fasted rats. Moreover, surface modification by CS or GCS effectively prevented the excretion of liposomes from the GI tract and prolonged retention in fed rats.
書誌情報 en : Drug development and industrial pharmacy

巻 44, 号 4, p. 608-614, 発行日 2017-11-30
DOI
値 10.1080/03639045.2017.1405972
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