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  1. 教員研究業績
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  3. 原著論文

Characterization of orally disintegrating films: A feasibility study using an electronic taste sensor and a flow-through cell

https://gifu-pu.repo.nii.ac.jp/records/13116
https://gifu-pu.repo.nii.ac.jp/records/13116
8770396d-6e51-4da7-bd82-eea17f30880a
Item type 研究室原著論文(1)
公開日 2017-03-14
タイトル
タイトル Characterization of orally disintegrating films: A feasibility study using an electronic taste sensor and a flow-through cell
言語
言語 eng
キーワード
主題Scheme Other
主題 Orally disintegrating film
キーワード
主題Scheme Other
主題 Electronic taste sensor
キーワード
主題Scheme Other
主題 Flow-through cell
キーワード
主題Scheme Other
主題 PullulanDonepezil hydrochloride
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
抄録
値 In the early development stage of orally disintegrating films (ODFs), suitable evaluation methods must be used. The aim of this study was to demonstrate the feasibility of using an electronic taste sensor and a flow-through cell for ODFs. A pullulan film loaded with donepezil hydrochloride (DH) was designed, as a model ODF. The film was prepared using the solution/solvent casting method. First, the dissolution profiles were compared by using a paddle method (PD) and a flow-through cell method (FT) under three flow rates. Dissolution tests using both methods were carried out successfully. Secondly, the bitterness of ODFs was determined by a new system combining a flow-through cell apparatus and an electronic taste sensor apparatus. The results indicated that the FT method can collect eluate for the bitterness test. They also suggested that these methods are useful for evaluating ODFs. The sensor output was strongly correlated with the dissolution behavior at the initial stage of administration. This new system with a flow-through cell and an electronic taste sensor could be used to evaluate the palatability of ODFs and to improve film formulation.
書誌情報 Journal of Drug Delivery Science and Technology

巻 39, p. 104-112, 発行日 2017-07
DOI
値 10.1016/j.jddst.2017.03.010
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