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Regioisomeric differentiation of synthetic cannabinoids with an N-fluorobenzyl indole core by gas chromatography–tandem mass spectrometry
https://gifu-pu.repo.nii.ac.jp/records/13266
https://gifu-pu.repo.nii.ac.jp/records/13266fc795d9c-20c7-4669-9749-095fd43a2728
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-06-20 | |||||
| タイトル | ||||||
| タイトル | Regioisomeric differentiation of synthetic cannabinoids with an N-fluorobenzyl indole core by gas chromatography–tandem mass spectrometry | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Synthetic cannabinoidsGC–MSRegioisomersFluorobenzyl indoleProduct ion spectra | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Differentiating halogen positional isomers of aromatic compounds using gas chromatography and mass spectrometry is a challenging task due to insufficient chromatographic separation and close similarity in the mass spectra of the isomers. For synthetic cannabinoids (SCs), a growing number of halogen derivatives have emerged, while there is no convenient and easily accessible procedure to differentiate the regioisomers of illegal drugs. In the current study, FUB-JWH-018 and its five isomers having structural and regioisomeric features were synthesized to investigate mass spectrometric differentiation by gas chromatography–electron ionization–tandem mass spectrometry (GC–EI–MS–MS). The ions at m/z 379, 378, and 362 were selected as precursor ions for this study based on their EI mass spectra. Differences in relative intensity of product ions were observed among the isomers, enabling feasible regioisomeric differentiation by mass spectrometry. Furthermore, high reproducibility of the product ion spectra at the optimized collision energy was confirmed and FUB-JWH-018 was successfully identified from illegal drug market products, demonstrating the reliability and practicality of the method. The characteristic properties in fragmentation with the mechanistic pathways are also described. This is the first report on mass spectrometric differentiation of the isomers of SCs bearing substituted regioisomeric fluorobenzyl moiety on 1H-indole core by GC–EI–MS–MS. The procedure has great potential to help in differentiating halogen positional isomers, providing clues to discriminate newly encountered designer drugs in the fields of analytical chemistry and forensic toxicology. | |||||
| 書誌情報 |
en : Forensic Chemistry 巻 6, p. 28-35, 発行日 2017-12 |
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| DOI | ||||||
| 値 | https://doi.org/10.1016/j.forc.2017.09.002 | |||||
