{"_buckets": {"deposit": "0183e9fb-191e-4062-8a89-6c3eef067930"}, "_deposit": {"created_by": 61, "id": "13450", "owners": [61], "pid": {"revision_id": 0, "type": "depid", "value": "13450"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00013450", "sets": ["259", "315"]}, "author_link": ["21759", "21760", "21756", "21757", "21755", "21754", "21758"], "item_10004_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}, {"bibliographic_title": "ChemMedChem", "bibliographic_titleLang": "en"}]}]}, "item_10004_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We developed new 10B carriers for boron neutron capture therapy (BNCT) that can effectively transport and accumulate boron clusters into cells. These carriers consist of lipopeptide, mercaptoundecahydrododecaborate (BSH) and a disulfide linker. The carriers were conceived according to the structure of pepducine, a membrane‐penetrating lipopeptide targeting protease‐activated receptor 1 (PAR1). To improve the membrane permeability of BSH, the structure was optimised using various lipopeptides possessing different peptides and lipid moieties. These synthesised lipopeptides were conjugated with BSH and evaluated for intracellular uptake using T98G glioblastoma cells. Among them, the most effectively incorporated and accumulated in the cells was compound 5a, which has a peptide of 13 residues derived from the intracellular third loop of PAR1 and a palmitoyl group. For further improvement of 10B accumulation in cells, the introduction of an amine linker was investigated; an intracellular uptake comparable to 5a was found for compound 14, which has a piperazine linker. Compound 5a and compound 14 both showed a stronger radio‐sensitising effect than BSH on T98G cells under mixed‐neutron beam irradiation. The results demonstrate that lipopeptide conjugation is apparently effective for enhancing intracellular delivery and accumulation of BSH and improving the cytotoxic effect of BNCT.", "subitem_description_type": "Abstract"}]}, "item_10004_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/cmdc.201800793", "subitem_relation_type_select": "DOI"}}]}, "item_10004_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "18607179", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Isono, Aoi"}], "nameIdentifiers": [{"nameIdentifier": "21754", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuji, Mieko"}], "nameIdentifiers": [{"nameIdentifier": "21755", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sanada, Yu"}], "nameIdentifiers": [{"nameIdentifier": "21756", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsushita, Akari"}], "nameIdentifiers": [{"nameIdentifier": "21757", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masunaga, Shinichiro"}], "nameIdentifiers": [{"nameIdentifier": "21758", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirayama, Tasuku"}], "nameIdentifiers": [{"nameIdentifier": "21759", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagasawa, Hideko"}], "nameIdentifiers": [{"nameIdentifier": "21760", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Design, Synthesis, and Evaluation of Lipopeptide Conjugates of Mercaptoundecahydrododecaborate for Boron Neutron Capture Therapy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Design, Synthesis, and Evaluation of Lipopeptide Conjugates of Mercaptoundecahydrododecaborate for Boron Neutron Capture Therapy", "subitem_title_language": "en"}]}, "item_type_id": "10004", "owner": "61", "path": ["259", "315"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/13450", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-03-04"}, "publish_date": "2019-03-04", "publish_status": "0", "recid": "13450", "relation": {}, "relation_version_is_last": true, "title": ["Design, Synthesis, and Evaluation of Lipopeptide Conjugates of Mercaptoundecahydrododecaborate for Boron Neutron Capture Therapy"], "weko_shared_id": -1}