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Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes
https://gifu-pu.repo.nii.ac.jp/records/13454
https://gifu-pu.repo.nii.ac.jp/records/1345440655490-700c-4629-a978-cef2bf7beb0e
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-04 | |||||
| タイトル | ||||||
| タイトル | Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Tasuku
× Hirayama, Tasuku× Miki, Ayaji× Nagasawa, Hideko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ferroptosis is an emerging type of cell death mode that is dependent of iron. Unfortunately, the detailed analysis of the function of organelle labile Fe(II) in oxidative damage and lethality of the cells has not been demonstrated so far, mainly due to the lack of efficient methods to visualize labile Fe(II) at the targeted organelles. We have recently reported a series of Fe(II)-selective fluorescent probes, i.e. Ac-MtFluNox, Lyso-RhoNox, and ER-SiRhoNox, which can detect Fe(II) specifically in mitochondria, lysosomes, and endoplasmic reticulum (ER), respectively. These probes demonstrate the similar reaction rates and off/on contrasts with various colours and intracellular distributions, enabling simultaneous multi-colour imaging that allows the monitoring of labile Fe(II) levels at each targeted organelle. In this paper, by using a cocktail of these probes, we successfully visualised the aberrant elevation of labile Fe(II) in lysosomes and ER prior to HT1080 cell death induced by erastin, which is an inducer of ferroptosis. | |||||
| 書誌情報 |
en : Metallomics 巻 11, 号 1, p. 111-117, 発行日 2019 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1756-5901 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/C8MT00212F | |||||
