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  1. 教員研究業績
  2. 薬化学研究室
  1. 教員研究業績
  2. 薬化学研究室
  3. 原著論文

Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes

https://gifu-pu.repo.nii.ac.jp/records/13454
https://gifu-pu.repo.nii.ac.jp/records/13454
40655490-700c-4629-a978-cef2bf7beb0e
Item type 会議発表論文 / Conference Paper(1)
公開日 2019-03-04
タイトル
言語 en
タイトル Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_5794
資源タイプ conference paper
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Hirayama, Tasuku

× Hirayama, Tasuku

WEKO 21780

Hirayama, Tasuku

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Miki, Ayaji

× Miki, Ayaji

WEKO 21781

Miki, Ayaji

Search repository
Nagasawa, Hideko

× Nagasawa, Hideko

WEKO 21782

Nagasawa, Hideko

Search repository
抄録
内容記述タイプ Abstract
内容記述 Ferroptosis is an emerging type of cell death mode that is dependent of iron. Unfortunately, the detailed analysis of the function of organelle labile Fe(II) in oxidative damage and lethality of the cells has not been demonstrated so far, mainly due to the lack of efficient methods to visualize labile Fe(II) at the targeted organelles. We have recently reported a series of Fe(II)-selective fluorescent probes, i.e. Ac-MtFluNox, Lyso-RhoNox, and ER-SiRhoNox, which can detect Fe(II) specifically in mitochondria, lysosomes, and endoplasmic reticulum (ER), respectively. These probes demonstrate the similar reaction rates and off/on contrasts with various colours and intracellular distributions, enabling simultaneous multi-colour imaging that allows the monitoring of labile Fe(II) levels at each targeted organelle. In this paper, by using a cocktail of these probes, we successfully visualised the aberrant elevation of labile Fe(II) in lysosomes and ER prior to HT1080 cell death induced by erastin, which is an inducer of ferroptosis.
書誌情報 en : Metallomics

巻 11, 号 1, p. 111-117, 発行日 2019
ISSN
収録物識別子タイプ ISSN
収録物識別子 1756-5901
DOI
識別子タイプ DOI
関連識別子 10.1039/C8MT00212F
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