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  1. 教員研究業績
  2. 薬化学研究室
  1. 教員研究業績
  2. 薬化学研究室
  3. 原著論文

Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)

https://gifu-pu.repo.nii.ac.jp/records/13456
https://gifu-pu.repo.nii.ac.jp/records/13456
cb38ea51-8b07-4e3f-bc26-c7093f161097
Item type 会議発表論文 / Conference Paper(1)
公開日 2019-03-04
タイトル
タイトル Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_5794
資源タイプ conference paper
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Hirako, Shima

× Hirako, Shima

WEKO 21790

Hirako, Shima

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Tsuda, Hiroyuki

× Tsuda, Hiroyuki

WEKO 21791

Tsuda, Hiroyuki

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Ito, Fumiya

× Ito, Fumiya

WEKO 21792

Ito, Fumiya

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Okazaki, Yasumasa

× Okazaki, Yasumasa

WEKO 21793

Okazaki, Yasumasa

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Hirayama, Tasuku

× Hirayama, Tasuku

WEKO 21794

Hirayama, Tasuku

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Nagasawa, Hideko

× Nagasawa, Hideko

WEKO 21795

Nagasawa, Hideko

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Nakano, Tomoko

× Nakano, Tomoko

WEKO 21796

Nakano, Tomoko

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Imai, Kenji

× Imai, Kenji

WEKO 21797

Imai, Kenji

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Kotani, Tomomi

× Kotani, Tomomi

WEKO 21798

Kotani, Tomomi

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Kikkawa, Fumitaka

× Kikkawa, Fumitaka

WEKO 21799

Kikkawa, Fumitaka

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Toyokuni, Shinya

× Toyokuni, Shinya

WEKO 21800

Toyokuni, Shinya

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抄録
内容記述タイプ Abstract
内容記述 Congenital diaphragmatic hernia (CDH) is a life-threatening neonatal disease that leads to lung hypoplasia and pulmonary hypertension. We recently found that maternal prenatal administration of Saireito (TJ-114) ameliorates fetal CDH in a nitrofen-induced rat model. Here, we studied the role of iron and oxidative stress in neonates of this model and in lung fibroblasts IMR90-SV in association with nitrofen and Saireito. We observed increased immunostaining of 8-hydroxy-2'-deoxyguanosine in the lungs of neonates with CDH, which was ameliorated by maternal Saireito intake. Pulmonary transferrin receptor expression was significantly decreased in both CDH and CDH after Saireito in comparison to normal controls, indicating functional lung immaturity, whereas catalytic Fe(II) and pulmonary DMT1/ferroportin expression remained constant among the three groups. Saireito revealed a dose-dependent scavenging capacity with electron spin resonance spin trapping in vitro against hydroxyl radicals but not against superoxide. Finally, nitrofen revealed dose-dependent cytotoxicity to IMR90-SV cells, accompanied by an increase in oxidative stress, as seen by 5(6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate and catalytic Fe(II). Saireito ameliorated all of these in IMR90-SV cells. In conclusion, catalytic Fe(II)-dependent oxidative stress by nitrofen may be the pathogenic cause of CDH, and the antioxidative activity of Saireito is at least partially responsible for improving nitrofen-induced CDH.
書誌情報 en : Journal of Clinical Biochemistry and Nutrition

巻 61, 号 3, p. 176-182, 発行日 2017
ISSN
収録物識別子タイプ ISSN
収録物識別子 0912-0009
DOI
識別子タイプ DOI
関連識別子 10.3164/jcbn.17-17
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