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Chemical tools for detecting Fe ions

https://gifu-pu.repo.nii.ac.jp/records/13462
https://gifu-pu.repo.nii.ac.jp/records/13462
27a73e14-c884-480d-866a-a83c36ce6114
Item type 会議発表論文 / Conference Paper(1)
公開日 2019-03-04
タイトル
タイトル Chemical tools for detecting Fe ions
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_5794
資源タイプ conference paper
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Hirayama, Tasuku

× Hirayama, Tasuku

WEKO 21842

Hirayama, Tasuku

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Nagasawa, Hideko

× Nagasawa, Hideko

WEKO 21843

Nagasawa, Hideko

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内容記述タイプ Abstract
内容記述 Owing to its distinctive electrochemical properties with interconvertible multiple oxidation states, iron plays a significant role in various physiologically important functions such as respiration, oxygen transport, energy production, and enzymatic reactions. This redox activity can also potentially produce cellular damage and death, and numerous diseases are related to iron overload resulting from the dysfunction of the iron regulatory system. In this case, “free iron” or “labile iron,” which refers to iron ion weakly bound or not bound to proteins, causes aberrant production of reactive oxygen species. With the aim of elucidating the variation of labile iron involved in pathological processes, some chemical tools that can qualitatively and/or quantitatively monitor iron have been utilized to investigate the distribution, accumulation, and flux of biological iron species. Since iron ions show unique reactivity depending on its redox state, i.e., Fe²⁺ or Fe³⁺ (or transiently higher oxidative states), methods for the separate detection of iron species with different redox states are preferred to understand its physiological and pathological roles more in detail. The scope of this review article covers from classical chromogenic to newly emerging chemical tools for the detection of Fe ions. In particular, chemical tools applicable to biological studies will be presented.
書誌情報 en : Journal of Clinical Biochemistry and Nutrition

巻 60, 号 1, p. 39-48, 発行日 2017
ISSN
収録物識別子タイプ ISSN
収録物識別子 0912-0009
DOI
識別子タイプ DOI
関連識別子 10.3164/jcbn.16-70
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