ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 教員研究業績
  2. 生化学研究室
  3. 原著論文

Sibutramine facilitates apoptosis and contraction of aortic smooth muscle cells through elevating production of reactive oxygen species.

https://gifu-pu.repo.nii.ac.jp/records/13468
https://gifu-pu.repo.nii.ac.jp/records/13468
38167dcd-3dee-48ea-98df-16d703fc8ec7
Item type 研究室原著論文(1)
公開日 2019-03-05
タイトル
タイトル Sibutramine facilitates apoptosis and contraction of aortic smooth muscle cells through elevating production of reactive oxygen species.
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Aorta
キーワード
言語 en
主題Scheme Other
主題 Apoptosis
キーワード
言語 en
主題Scheme Other
主題 Cyclobutanes
キーワード
言語 en
主題Scheme Other
主題 Humans
キーワード
言語 en
主題Scheme Other
主題 Muscle, Smooth, Vascular
キーワード
言語 en
主題Scheme Other
主題 Nitric Oxide
キーワード
言語 en
主題Scheme Other
主題 Reactive Oxygen Species
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
item_3_textarea_2
値 Sibutramine had been prescribed as an oral anorexiant that reduces dietary intake, but was withdrawn from the market due to frequent occurrence of severe cardiovascular events including hypertension. To elucidate the pathogenic mechanism of hypertension, we here investigated whether sibutramine facilitates damage and contraction of human aortic smooth muscle (HASM) cells or not. Treatment with sibutramine provoked HASM cell apoptosis, which was attributed to production of reactive oxygen species and mitochondria dysfunction. In addition, the drug treatment of the cell promoted calcium influx, phosphorylation of myosin light chain and contraction, which were abrogated by pretreating the cells with antioxidant and nitric oxide (NO) donor. Thus, the drug-evoked contraction is likely due to a preceding disturbance of balance between the drug-elicited reactive oxygen species production and exogenous NO supply. Compared to sibutramine, its N-desmethyl and N-didesmethyl metabolites exhibited much less toxicity and contraction against HASM cells, in which sibutramine was hardly demethylated. The low metabolic capacity of the cells may also be pertinent to the damage and contraction elicited by sibutramine. Taken together, our data suggest that sibutramine facilitates apoptosis and contraction of aortic smooth muscle cells through elevating production of reactive oxygen species and decreasing exogenous NO supply, leading to pathogenesis of hypertension.
bibliographic_information en : European journal of pharmacology

巻 841, 号 -, p. 113-121, ページ数 9, 発行日 2018-12-15
item_3_text_4
値 10.1016/j.ejphar.2018.10.009.
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-19 08:48:07.801244
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3