ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 教員研究業績
  2. 製剤学研究室
  3. 原著論文

Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation.

https://gifu-pu.repo.nii.ac.jp/records/14296
https://gifu-pu.repo.nii.ac.jp/records/14296
9b397a62-a8f9-4748-bc16-499d761e99f6
Item type 研究室原著論文(1)
公開日 2021-02-17
タイトル
タイトル Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation.
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 desmoglein 3
キーワード
言語 en
主題Scheme Other
主題 keratinocyte
キーワード
言語 en
主題Scheme Other
主題 psoriasis
キーワード
言語 en
主題Scheme Other
主題 lipid-polymer nanohybrid
キーワード
言語 en
主題Scheme Other
主題 active targeting
キーワード
言語 en
主題Scheme Other
主題 monovalent antibody
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
item_3_textarea_2
値 To improve the treatment of psoriasiform inflammation, we developed actively targeted nanocarriers loaded with the phosphodiesterase 4 inhibitor AN2728.
Methods: Phospholipid-poly(lactic-co-glycolic acid) nanohybrids were prepared and conjugated with monovalent anti-desmoglein 3 antibody to bind keratinocytes.
Results: The actively targeted nanohybrids were 229 nm in mean size with a nearly neutral surface charge. Flow cytometry and confocal microscopy showed a 9-fold increase in keratinocyte uptake of targeted nanohybrids relative to non-targeted nanoparticles. The nanoparticles localized mainly in lysosomes after internalization. AN2728-loaded antibody-conjugated nanocarriers inhibited cytokine/chemokine overexpression in activated keratinocytes without affecting cell viability. The targeted nanohybrids also suppressed neutrophil migration by reducing CXCL1 and CXCL2 release from keratinocytes. Following subcutaneous administration in mice, the nanohybrids distributed to the epidermis and hair follicles. In a psoriasis-like skin mouse model, the actively targeted nanoparticles were superior to free drug and non-targeted nanoparticles in mitigating skin inflammation. Intervention with the targeted nanosystem reduced the epidermal thickness of the psoriasiform lesion from 191 to 42 μm, decreased the Psoriasis Area Severity Index by 74%, restored barrier function, and returned chemokine levels to baseline.
Conclusions: Our developed nanosystem was safe and demonstrated efficient targeting properties for the treatment of cutaneous inflammation.
bibliographic_information en : Theranostics

巻 11, 号 10, p. 4567-4584, ページ数 18, 発行日 2021-02-17
item_3_text_4
値 10.7150/thno.56995
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-19 07:44:08.546846
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3