{"_buckets": {"deposit": "42934d3a-6afd-4a71-b51d-0311e8b036c3"}, "_deposit": {"created_by": 122, "id": "14297", "owners": [122], "pid": {"revision_id": 0, "type": "depid", "value": "14297"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00014297", "sets": ["253", "333"]}, "author_link": ["33122", "33123", "33124"], "item_3_biblio_info_3": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueNumber": "25", "bibliographicPageStart": "120148", "bibliographicVolumeNumber": "593", "bibliographic_titles": [{}, {"bibliographic_title": "International Journal of Pharmaceutics", "bibliographic_titleLang": "en"}]}]}, "item_3_text_4": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_text_value": "https://doi.org/10.1016/j.ijpharm.2020.120148"}]}, "item_3_textarea_2": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_textarea_value": "We investigated the feasibility of densely polyethylene glycol (PEG2000)-modified liposomes as mucus-penetrating particles (MPPs) for oral delivery of systemically absorbed peptides. The oral absorption of MPPs and mucoadhesive liposomes modified with glycol chitosan (GCS) was compared. In an in vitro artificial mucus model, the densely PEGylated liposomes showed mucus permeability. Intracellular uptake of liposomes was evaluated in a Caco-2 and mucus-secreting Caco-2/HT29 co-culture. Intracellular uptake of MPPs was unaffected by mucus in the co-culture system, whereas the cellular uptake of GCS-liposomes was lower with a mucus layer than in Caco-2 alone. Rat in vivo oral absorption of liposomes was evaluated by using fluorescein isothiocyanate dextran (FD) as a model peptide drug. Oral absorption was higher for densely PEGylated than for unmodified liposomes and was PEG-concentration dependent, but excessive PEGylation decreased FD blood concentration. PEGylated liposomes incorporating spermine (SPM) as an absorption enhancer were then designed and showed the highest in vivo absorption of FD of all tested formulations. The pharmacological effects of the oral liposomes were evaluated by using elcatonin and did not correlate with FD oral absorption. The non-PEGylated SPM liposomes showed the highest pharmacological effect, suggesting the need for drug-specific optimization of liposomal components and surface modifiers."}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome."}, {"subitem_title": "Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome.", "subitem_title_language": "en"}]}, "item_type_id": "3", "owner": "122", "path": ["253", "333"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/14297", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-12-01"}, "publish_date": "2020-12-01", "publish_status": "0", "recid": "14297", "relation": {}, "relation_version_is_last": true, "title": ["Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome."], "weko_shared_id": -1}