ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "43281af3-09e0-48f5-b604-694abf4fbc55"}, "_deposit": {"created_by": 122, "id": "14298", "owners": [122], "pid": {"revision_id": 0, "type": "depid", "value": "14298"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00014298", "sets": ["253", "333"]}, "author_link": ["33126", "33125", "33128", "33127"], "item_3_biblio_info_3": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueNumber": "101999", "bibliographicVolumeNumber": "60", "bibliographic_titles": [{"bibliographic_title": "Journal of Drug Delivery Science and Technology"}, {"bibliographic_title": "Journal of Drug Delivery Science and Technology", "bibliographic_titleLang": "en"}]}]}, "item_3_textarea_2": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_textarea_value": "In the present study, surface-modified punches with different roughness were evaluated for their ability to prevent sticking during pharmaceutical tableting using a single punch machine. The surface roughness of the punch faces was assessed using a laser microscope. Acetaminophen and ibuprofen were used as model active pharmaceutical ingredients (APIs) for the tableting tests. The amounts of API powders adhering to the punch faces after tableting were evaluated using spectrophotometric methods. Although the surfaces of the pre-treated punch faces were developed to prevent sticking during tableting, the sticking prevention was greater for acetaminophen than ibuprofen, and the sticking prevention was shown to depend on the mechanical properties of the API powders—namely, plasticity and elasticity. During continuous tableting the formulations, the surface-modified punches maintained their anti-sticking properties. We concluded that characterization of the sticking properties by the present methods using a single punch machine is useful (1) to select the most suitable type of punch face for tableting a drug formulation without a large loss of expensive APIs, and (2) to solve the sticking problems without changing the pharmaceutical formulations during manufacturing."}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting."}, {"subitem_title": "Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting.", "subitem_title_language": "en"}]}, "item_type_id": "3", "owner": "122", "path": ["253", "333"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/14298", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-08-11"}, "publish_date": "2020-08-11", "publish_status": "0", "recid": "14298", "relation": {}, "relation_version_is_last": true, "title": ["Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting."], "weko_shared_id": -1}
  1. 教員研究業績
  2. 製剤学研究室
  1. 教員研究業績
  2. 製剤学研究室
  3. 原著論文

Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting.

https://gifu-pu.repo.nii.ac.jp/records/14298
https://gifu-pu.repo.nii.ac.jp/records/14298
84b6933f-a058-495c-ad98-56b20bbcea1c
Item type 研究室原著論文(1)
公開日 2020-08-11
タイトル
タイトル Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting.
タイトル
言語 en
タイトル Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
抄録
値 In the present study, surface-modified punches with different roughness were evaluated for their ability to prevent sticking during pharmaceutical tableting using a single punch machine. The surface roughness of the punch faces was assessed using a laser microscope. Acetaminophen and ibuprofen were used as model active pharmaceutical ingredients (APIs) for the tableting tests. The amounts of API powders adhering to the punch faces after tableting were evaluated using spectrophotometric methods. Although the surfaces of the pre-treated punch faces were developed to prevent sticking during tableting, the sticking prevention was greater for acetaminophen than ibuprofen, and the sticking prevention was shown to depend on the mechanical properties of the API powders—namely, plasticity and elasticity. During continuous tableting the formulations, the surface-modified punches maintained their anti-sticking properties. We concluded that characterization of the sticking properties by the present methods using a single punch machine is useful (1) to select the most suitable type of punch face for tableting a drug formulation without a large loss of expensive APIs, and (2) to solve the sticking problems without changing the pharmaceutical formulations during manufacturing.
書誌情報 Journal of Drug Delivery Science and Technology
en : Journal of Drug Delivery Science and Technology

巻 60, 号 101999
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-19 07:44:07.422108
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3