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Orally disintegrating films: The effects of water content on disintegration and mechanical properties
https://gifu-pu.repo.nii.ac.jp/records/14503
https://gifu-pu.repo.nii.ac.jp/records/145031c6eb6b0-005a-4400-a6a4-d89dd7f54d5a
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-04 | |||||
| タイトル | ||||||
| タイトル | Orally disintegrating films: The effects of water content on disintegration and mechanical properties | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Orally disintegrating films (ODFs) are one of the most important pharmaceutical oral dosage forms. However, it has been noted that the hygroscopicity of ODFs damages their stability and mechanical strength. We prepared model ODFs with three different water contents by storage under different relative humidity conditions in order to examine the effect of the water content on the films’ mechanical properties and the disintegration time. We used three molecular-weight (MW) grades of hydroxypropyl celluloses (HPCs), polyvinyl alcohol (PVA) and pullulan (PUL) as film-formers, and glycerin (GLY) as a plasticizer. With increases of the water content, the ODFs showed significantly decreased tensile strength but no marked change in disintegration time. Water content had the greatest effect on the PVA films containing GLY (10–20%). In addition, PUL films showed the highest water adsorption under all humidity conditions but maintained their excellent mechanical properties. We also elucidated the hygroscopicity of the ODFs formulated with the different polymers and plasticizer by means of a dynamic vapor sorption (DVS) analysis. Our findings provide useful information about the effects of different water contents and storage conditions on ODFs. | |||||
| 書誌情報 |
en : Journal of Drug Delivery Science and Technology 巻 66, p. 102893, 発行日 2021 |
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