{"_buckets": {"deposit": "e51f71dc-38c6-4d02-a170-d327ba059d8f"}, "_deposit": {"created_by": 140, "id": "14857", "owners": [140], "pid": {"revision_id": 0, "type": "depid", "value": "14857"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00014857", "sets": ["345"]}, "author_link": ["36622", "32440"], "item_10004_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "33", "bibliographicPageEnd": "21740", "bibliographicPageStart": "21730", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{}, {"bibliographic_title": "ACS Omega", "bibliographic_titleLang": "en"}]}]}, "item_10004_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Electrochemical analyses aided by density functional theory calculations were used to investigate the oxidative degradation of pyrazine antiviral drugs, 3-hydroxypyrazine-2-carboxamide (T-1105) and 6-fluoro-3-hydroxypyrazine-2-carboxamide (favipiravir, T-705), by the electrogenerated superoxide radical anion (O2•–). T-1105 and T-705 are antiviral RNA nucleobase analogues that selectively inhibit the RNA-dependent RNA polymerase. They are expected as a drug candidate against various viral infections, including COVID-19. The pyrazine moiety was decomposed by O2•– through proton-coupled electron transfer (PCET). Our results show that its active form, pyrazine-ribofuranosyl-5′-triphosphate, is easily oxidized under inflamed organs by overproduced O2•– through the PCET mechanism in the immune system. This mechanistic study implies that the oxidative degradation of pyrazine derivatives will be prevented by controlling the PCET through simple modification of the pyrazine structure.", "subitem_description_type": "Abstract"}]}, "item_10004_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "american chemical society"}]}, "item_10004_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1021/acsomega.1c03230", "subitem_relation_type_select": "DOI"}}]}, "item_10004_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2470-1343", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "nakayama, tatsushi"}], "nameIdentifiers": [{"nameIdentifier": "32440", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "N000638361", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/N000638361"}]}, {"creatorNames": [{"creatorName": "Honda, Ryo"}], "nameIdentifiers": [{"nameIdentifier": "36622", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-03-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "acsomega.1c03230.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "acsomega.1c03230", "url": "https://gifu-pu.repo.nii.ac.jp/record/14857/files/acsomega.1c03230.pdf"}, "version_id": "7768e417-05ba-4ac8-b91e-64cb2cc2133d"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer"}, {"subitem_title": "Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer", "subitem_title_language": "en"}]}, "item_type_id": "10004", "owner": "140", "path": ["345"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/14857", "pubdate": {"attribute_name": "公開日", "attribute_value": "2023-03-20"}, "publish_date": "2023-03-20", "publish_status": "0", "recid": "14857", "relation": {}, "relation_version_is_last": true, "title": ["Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer"], "weko_shared_id": -1}