{"_buckets": {"deposit": "4e75240a-3891-45eb-a850-7f09aed689c9"}, "_deposit": {"created_by": 5, "id": "7980", "owners": [5], "pid": {"revision_id": 0, "type": "depid", "value": "7980"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00007980", "sets": ["182"]}, "author_link": ["14083", "26385", "14084", "25841", "17785", "22461", "5541", "26387", "23990", "26386", "26388"], "item_1_alternative_title_5": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_alternative_title": "〓"}]}, "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1986-06-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "44", "bibliographicPageStart": "36", "bibliographicVolumeNumber": "35", "bibliographic_titles": [{"bibliographic_title": "岐阜藥科大學紀要"}, {"bibliographic_title": "The annual proceedings of Gifu College of Pharmacy", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "徐, 強"}], "nameIdentifiers": [{"nameIdentifier": "26385", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小野, 裕"}], "nameIdentifiers": [{"nameIdentifier": "26386", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森, 裕志"}], "nameIdentifiers": [{"nameIdentifier": "26387", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "江田, 昭英"}], "nameIdentifiers": [{"nameIdentifier": "14083", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_7": {"attribute_name": "著者名よみ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "オノ, ユタカ"}], "nameIdentifiers": [{"nameIdentifier": "26388", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "モリ, ヒロシ"}], "nameIdentifiers": [{"nameIdentifier": "17785", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "コウダ, アキヒデ"}], "nameIdentifiers": [{"nameIdentifier": "14084", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_8": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "XU, QIANG", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22461", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ONO, YUTAKA", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "25841", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MORI, HIROSHI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "23990", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KODA, AKIHIDE", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5541", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "キンミズヒキのタンニンの1種であるagrimoniinの抗腫瘍作用を検討した。AgrimoniinはC57BL/6マウスに移植したE.L.4およびBALB/cマウスに移植したMethA腫瘍の増殖を有意に抑制し, MethAを移植したマウスの生存期間の延長傾向を示した。また, agrimoniinはE.L.4,MethAおよびL-929細胞に対してin vitroで用量依存的な障害作用を示し, その細胞障害性は4時間以内のincubationによってみられた。一方, agrimoniinはヒツジ赤血球で免疫したhemolytic plaque forming cellおよびhemolysinの産生に影響を及ぼさず, また, picrylchlorideによる細胞性免疫の成立に対しても影響を及ぼさなかった。以上のことから, agrimoniinはキンミズヒキの抗腫瘍成分の一つであり, その作用機序は直接的な細胞障害作用によるものと思われる。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Studies were carried out to examine the antitumor activity of agrimoniin, one of tannins isolated from Agrimonia pilosa Ledeb., using syngeneic systems including C57BL/6 mice-E.L.4 lymphosarcoma and BALB/C mice-Meth A fibrosarcoma, and the effect on immune responses. Agrimoniin significantly inhibited the growth of both the tumors and showed a tendency to prolong the survival period of BALB/C mice bearing Meth A fibrosarcoma. In the in vitro study the tannin also exhibited a cytotoxic activity against E. L. 4 lymphosarcoma, Meth A fibrosarcoma and L-929 cells in a dosedependent fashion, and the activity was seen within 4 hour-incubation. Agrimoniin, however, neither affected the production of humoral antibodies such as hemolytic plaque forming cell and hemolysin against sheep red blood cells nor the formation of cellular immune response induced by picryl chloride These results suggest that agrimoniin may be one of the antitumor constituents of A. pilosa and display the activity through the direct cytotoxicity rather than host-mediated mechanism.", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00053514", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pharmacology, Gifu Pharmaceutical University/Department of Pharmacology, Gifu Pharmaceutical University/Department of Pharmacology, Gifu Pharmaceutical University/Department of Pharmacology, Gifu Pharmaceutical University"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/岐阜薬科大学"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "1986-06-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000071906.pdf", "filesize": [{"value": "532.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 532000.0, "url": {"url": "https://gifu-pu.repo.nii.ac.jp/record/7980/files/KJ00000071906.pdf"}, "version_id": "0ab66ac6-6c2a-40de-9bf5-c9405cd9ba67"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u003c一般論文\u003eAgrimoniinの抗腫瘍作用および免疫反応に及ぼす影響", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "\u003c一般論文\u003eAgrimoniinの抗腫瘍作用および免疫反応に及ぼす影響"}, {"subitem_title": "Antitumor Activity and the Effect on Immune Responses of Agrimoniin", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "5", "path": ["182"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/7980", "pubdate": {"attribute_name": "公開日", "attribute_value": "1986-06-30"}, "publish_date": "1986-06-30", "publish_status": "0", "recid": "7980", "relation": {}, "relation_version_is_last": true, "title": ["\u003c一般論文\u003eAgrimoniinの抗腫瘍作用および免疫反応に及ぼす影響"], "weko_shared_id": 5}