{"_buckets": {"deposit": "b3fec2ce-e263-4842-b73a-581ffa61ba91"}, "_deposit": {"created_by": 5, "id": "9081", "owners": [5], "pid": {"revision_id": 0, "type": "depid", "value": "9081"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00009081", "sets": ["188"]}, "author_link": ["25104", "25107", "21252", "25102", "21248", "21253", "24571", "21249", "23936", "25101", "25105", "21257", "25103", "25106", "21256"], "item_1_alternative_title_5": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_alternative_title": "〓"}]}, "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-06-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "36", "bibliographicPageStart": "30", "bibliographicVolumeNumber": "41", "bibliographic_titles": [{"bibliographic_title": "岐阜藥科大學紀要"}, {"bibliographic_title": "The annual proceedings of Gifu College of Pharmacy", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "澤田, 英夫"}], "nameIdentifiers": [{"nameIdentifier": "25101", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "浜武, 通子"}], "nameIdentifiers": [{"nameIdentifier": "25102", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "原, 明"}], "nameIdentifiers": [{"nameIdentifier": "21248", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中山, 俊裕"}], "nameIdentifiers": [{"nameIdentifier": "21249", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "出屋敷, 喜宏"}], "nameIdentifiers": [{"nameIdentifier": "25103", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_7": {"attribute_name": "著者名よみ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "サワダ, ヒデオ"}], "nameIdentifiers": [{"nameIdentifier": "25104", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ハマタケ, ミチコ"}], "nameIdentifiers": [{"nameIdentifier": "25105", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ハラ, アキラ"}], "nameIdentifiers": [{"nameIdentifier": "21252", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ナカヤマ, トシヒロ"}], "nameIdentifiers": [{"nameIdentifier": "21253", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "デヤシキ, ヨシヒロ"}], "nameIdentifiers": [{"nameIdentifier": "25106", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_8": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SAWADA, HIDEO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24571", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HAMATAKE, MICHIKO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "25107", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HARA, AKIRA", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "21256", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAKAYAMA, TOSHIHIRO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "21257", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "DEYASHIKI, YOSHIHIRO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "23936", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "ヒト胎盤およびブタ水晶体と筋肉から精製したアルドース還元酵素に及ぼす加水分解型および縮合型タンニンの阻害を比較した。ガロタンニンは他のタンニンより強くこれらの酵素を阻害し, このうち1,2,3,4,6-penta-O-galloyl-β-D-glucose(PGG)が最も低いIC_\u003c50\u003e値(60-70nM)を示した。PGGはアルコール脱水素酵素, アルデヒド還元酵素, カルボニル還元酵素に対して低度の阻害しか示さなかった。PGGによるアルドース還元酵素の阻害様式はカルボニル基質に対して混合型であったが, 活性化剤である硫酸イオン存在下では不拮抗型となった。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "The inhibitory effects of various hydrolyzable and condensed tannins for aldose reductases of human placenta, pig lens and pig muscle were examined and compared. Gallotannins inhibited these enzymes much more than other tannins with 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) showing the lowest IC_\u003c50\u003e values (60-70 nM). PGG had low inhibitory effect on aldehyde reductase, carbonyl reductase and alcohol dehydrogenase. The inhibition of aldose reductase by PGG was of the mixed type with respect to the carbonyl substrate, but the inhibition was found to be uncompetitive when assaying enzyme activity in the presence of sulfate ions, an activator of the enzyme.", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00053514", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University/Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University/Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University/Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University/Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/岐阜薬科大学"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "1992-06-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000072717.pdf", "filesize": [{"value": "420.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 420100.0, "url": {"url": "https://gifu-pu.repo.nii.ac.jp/record/9081/files/KJ00000072717.pdf"}, "version_id": "f7f3485e-d394-4615-8d42-f03b5162c40c"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u003c一般論文\u003eガロタンニンによるアルドース還元酵素の阻害について", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "\u003c一般論文\u003eガロタンニンによるアルドース還元酵素の阻害について"}, {"subitem_title": "\u003cRegular Article\u003eInhibition of Aldose Reductase by Gallotannin", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "5", "path": ["188"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/9081", "pubdate": {"attribute_name": "公開日", "attribute_value": "1992-06-30"}, "publish_date": "1992-06-30", "publish_status": "0", "recid": "9081", "relation": {}, "relation_version_is_last": true, "title": ["\u003c一般論文\u003eガロタンニンによるアルドース還元酵素の阻害について"], "weko_shared_id": 5}