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  1. 岐阜藥科大學紀要
  2. 41号(平成4年6月30日発行)

<一般論文>ガロタンニンによるアルドース還元酵素の阻害について

https://gifu-pu.repo.nii.ac.jp/records/9081
https://gifu-pu.repo.nii.ac.jp/records/9081
f5ce654c-24cf-419b-959d-c5986efb8737
名前 / ファイル ライセンス アクション
KJ00000072717.pdf KJ00000072717.pdf (420.1 kB)
Item type 紀要論文(ELS) / Departmental Bulletin Paper(1)
公開日 1992-06-30
タイトル
タイトル <一般論文>ガロタンニンによるアルドース還元酵素の阻害について
タイトル
言語 en
タイトル <Regular Article>Inhibition of Aldose Reductase by Gallotannin
言語
言語 jpn
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ページ属性
内容記述タイプ Other
内容記述 P(論文)
論文名よみ
その他のタイトル 〓
著者名(日) 澤田, 英夫

× 澤田, 英夫

WEKO 25101

澤田, 英夫

Search repository
浜武, 通子

× 浜武, 通子

WEKO 25102

浜武, 通子

Search repository
原, 明

× 原, 明

WEKO 21248

原, 明

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中山, 俊裕

× 中山, 俊裕

WEKO 21249

中山, 俊裕

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出屋敷, 喜宏

× 出屋敷, 喜宏

WEKO 25103

出屋敷, 喜宏

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著者名よみ サワダ, ヒデオ

× サワダ, ヒデオ

WEKO 25104

サワダ, ヒデオ

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ハマタケ, ミチコ

× ハマタケ, ミチコ

WEKO 25105

ハマタケ, ミチコ

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ハラ, アキラ

× ハラ, アキラ

WEKO 21252

ハラ, アキラ

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ナカヤマ, トシヒロ

× ナカヤマ, トシヒロ

WEKO 21253

ナカヤマ, トシヒロ

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デヤシキ, ヨシヒロ

× デヤシキ, ヨシヒロ

WEKO 25106

デヤシキ, ヨシヒロ

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著者名(英) SAWADA, HIDEO

× SAWADA, HIDEO

WEKO 24571

en SAWADA, HIDEO

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HAMATAKE, MICHIKO

× HAMATAKE, MICHIKO

WEKO 25107

en HAMATAKE, MICHIKO

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HARA, AKIRA

× HARA, AKIRA

WEKO 21256

en HARA, AKIRA

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NAKAYAMA, TOSHIHIRO

× NAKAYAMA, TOSHIHIRO

WEKO 21257

en NAKAYAMA, TOSHIHIRO

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DEYASHIKI, YOSHIHIRO

× DEYASHIKI, YOSHIHIRO

WEKO 23936

en DEYASHIKI, YOSHIHIRO

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著者所属(日)
値 岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/岐阜薬科大学
著者所属(英)
言語 en
値 Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University/Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University/Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University/Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University/Laboratory of Biochemistry, Department of Manufacturing Pharmacy, Gifu Pharmaceutical University
抄録(日)
内容記述タイプ Other
内容記述 ヒト胎盤およびブタ水晶体と筋肉から精製したアルドース還元酵素に及ぼす加水分解型および縮合型タンニンの阻害を比較した。ガロタンニンは他のタンニンより強くこれらの酵素を阻害し, このうち1,2,3,4,6-penta-O-galloyl-β-D-glucose(PGG)が最も低いIC_<50>値(60-70nM)を示した。PGGはアルコール脱水素酵素, アルデヒド還元酵素, カルボニル還元酵素に対して低度の阻害しか示さなかった。PGGによるアルドース還元酵素の阻害様式はカルボニル基質に対して混合型であったが, 活性化剤である硫酸イオン存在下では不拮抗型となった。
抄録(英)
内容記述タイプ Other
内容記述 The inhibitory effects of various hydrolyzable and condensed tannins for aldose reductases of human placenta, pig lens and pig muscle were examined and compared. Gallotannins inhibited these enzymes much more than other tannins with 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) showing the lowest IC_<50> values (60-70 nM). PGG had low inhibitory effect on aldehyde reductase, carbonyl reductase and alcohol dehydrogenase. The inhibition of aldose reductase by PGG was of the mixed type with respect to the carbonyl substrate, but the inhibition was found to be uncompetitive when assaying enzyme activity in the presence of sulfate ions, an activator of the enzyme.
雑誌書誌ID
収録物識別子タイプ NCID
収録物識別子 AN00053514
書誌情報 岐阜藥科大學紀要
en : The annual proceedings of Gifu College of Pharmacy

巻 41, p. 30-36, 発行日 1992-06-30
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