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  1. 教員研究業績
  2. 病院薬学研究室
  3. 原著論文

Evaluation of antimicrobial stewardship (AS) for appropriate use of antimicrobial agents.

https://gifu-pu.repo.nii.ac.jp/records/13287
https://gifu-pu.repo.nii.ac.jp/records/13287
4d086c86-397b-4919-8a49-4b6c88602162
Item type 研究室原著論文(1)
公開日 2018-07-06
タイトル
タイトル Evaluation of antimicrobial stewardship (AS) for appropriate use of antimicrobial agents.
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
抄録
値 We implemented an antimicrobial stewardship (AS) program whereby pharmacists sought appropriate use of antimicrobial agents in January 2012. At that time, we targeted anti-methicillin-resistant Staphylococcus aureus (MRSA) agents and carbapenems; however, in January 2014, we added tazobactam/piperacillin (TAZ/PIPC). We evaluated outcomes using multilateral analyses. The average one-day dosage of carbapenems increased; however, the duration of administration and number of recipient patients decreased significantly (P < 0.01). Moreover, the percentage of patients receiving meropenem (MEPM), for whom the time above minimal inhibitory concentration (MIC) was 40% or higher increased (P < 0.01). In contrast, patient utilization of TAZ/PIPC increased significantly after targeting of carbapenems as specific antibacterial agents. However, after TAZ/PIPC was targeted as a specific antibacterial agent, the number of TAZ/PIPC administrations decreased significantly (P < 0.01). The duration of hospitalization and mortality rate in patients receiving specific antibacterial agents significantly decreased after implementation of the AS program (P < 0.01). In conclusion, pharmacist's interventions to provide AS and patient follow-up reduced improper use and promoted proper administration of antibacterial agents. Furthermore, AS was effective in improving patient prognoses and suppressing drug-resistant strains, as well as promoting effective treatment.
書誌情報 en : Die Pharmazie

巻 72, 号 5, p. 296-299, 発行日 2017-05-01
DOI
値 10.1691/ph.2017.6968
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