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Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke
https://gifu-pu.repo.nii.ac.jp/records/14043
https://gifu-pu.repo.nii.ac.jp/records/140433d5cb16b-9d77-4662-a152-a3ebade1c549
Item type | 研究室原著論文(1) | |||||
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公開日 | 2020-09-08 | |||||
タイトル | ||||||
タイトル | Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
抄録 | ||||||
値 | Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert antioxidative effects on macrophages and cardiomyocytes. Here, we demonstrated the neuroprotective effects of 5-ALA using rat models of PD and ischemia as well as in vitro in SH-SY5Y cells. 5-ALA partially prevented neurodegeneration in each condition. These results suggest that 5-ALA has a potential for promising therapeutic agent to protect against neurodegeneration exacerbated by oxidative stress. | |||||
書誌情報 |
Journal of Pharmacological Sciences en : Journal of Pharmacological Sciences 巻 S1347-8613, 号 20, p. 30077-3, 発行日 2020-08-01 |
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DOI | ||||||
値 | 10.1016/j.jphs.2020.07.012. |