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Synthesis and Characterization of Polymer-Linked Prodrug of Antibacterial Agent for The Targeted Delivery to The Colon by Cold Plasma Technique
https://gifu-pu.repo.nii.ac.jp/records/14094
https://gifu-pu.repo.nii.ac.jp/records/14094b23ebea9-c606-4c21-9a1a-ca189b352dd9
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-09-10 | |||||
| タイトル | ||||||
| タイトル | Synthesis and Characterization of Polymer-Linked Prodrug of Antibacterial Agent for The Targeted Delivery to The Colon by Cold Plasma Technique | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Plasma irradiation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Drug delivery system | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Antibacterial agent | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Polymeric prodrugs | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | A crystalline acrylic-type polymerizable monomer of Nalidixic acid (NA) was synthesized by linking NA molecule to acrylic acid (AA) via acid-anhydride conjugate. Then, the monomer was polymerized in solid state by vibratory mixing with plasma-irradiated lactose powders as postprocessing-free initiators. The characterization of the resulting polymeric prodrug powders by ESR, XRPD and FT-IR analysis confirmed their synthesis successfully. The in vitro hydrolysis study of the polymeric prodrugs was carried out in three different buffer solutions at 37 ℃. The results indicated that the acid-anhydride conjugate of the polymeric prodrugs was relatively stable to acid-catalyzed hydrolysis, and the NA release was in sustained manner with no burst and enhanced in basic media, in which ca. 4%, 35% and 80% of NA was released in 12 h at pH 1.2, pH 6.8 and pH 8.5, respectively. The obtained results suggested that the studied systems could be potential antibacterial polymeric prodrugs to minimize drug-stomach exposure and to use for colonic-targeting drug delivery formulation. | |||||
| 書誌情報 |
en : Journal of Photopolymer Science and Technology 巻 33, 号 3, p. 343-348, 発行日 2020-07-01 |
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| DOI | ||||||
| 値 | 10.2494/photopolymer.33.343 | |||||
