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  1. 教員研究業績
  2. 薬品物理化学研究室
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Synthesis and Characterization of Polymer-Linked Prodrug of Antibacterial Agent for The Targeted Delivery to The Colon by Cold Plasma Technique

https://gifu-pu.repo.nii.ac.jp/records/14094
https://gifu-pu.repo.nii.ac.jp/records/14094
b23ebea9-c606-4c21-9a1a-ca189b352dd9
Item type 研究室原著論文(1)
公開日 2020-09-10
タイトル
タイトル Synthesis and Characterization of Polymer-Linked Prodrug of Antibacterial Agent for The Targeted Delivery to The Colon by Cold Plasma Technique
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Plasma irradiation
キーワード
言語 en
主題Scheme Other
主題 Drug delivery system
キーワード
言語 en
主題Scheme Other
主題 Antibacterial agent
キーワード
言語 en
主題Scheme Other
主題 Polymeric prodrugs
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
抄録
値 A crystalline acrylic-type polymerizable monomer of Nalidixic acid (NA) was synthesized by linking NA molecule to acrylic acid (AA) via acid-anhydride conjugate. Then, the monomer was polymerized in solid state by vibratory mixing with plasma-irradiated lactose powders as postprocessing-free initiators. The characterization of the resulting polymeric prodrug powders by ESR, XRPD and FT-IR analysis confirmed their synthesis successfully. The in vitro hydrolysis study of the polymeric prodrugs was carried out in three different buffer solutions at 37 ℃. The results indicated that the acid-anhydride conjugate of the polymeric prodrugs was relatively stable to acid-catalyzed hydrolysis, and the NA release was in sustained manner with no burst and enhanced in basic media, in which ca. 4%, 35% and 80% of NA was released in 12 h at pH 1.2, pH 6.8 and pH 8.5, respectively. The obtained results suggested that the studied systems could be potential antibacterial polymeric prodrugs to minimize drug-stomach exposure and to use for colonic-targeting drug delivery formulation.
書誌情報 en : Journal of Photopolymer Science and Technology

巻 33, 号 3, p. 343-348, 発行日 2020-07-01
DOI
値 10.2494/photopolymer.33.343
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