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  1. 教員研究業績
  2. 薬効解析学研究室
  3. 原著論文

The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells

https://gifu-pu.repo.nii.ac.jp/records/14149
https://gifu-pu.repo.nii.ac.jp/records/14149
a3f78a3a-3fd2-45e7-a813-168d0967c228
Item type 研究室原著論文(1)
公開日 2020-09-11
タイトル
タイトル The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
抄録
値 The cornea is located on the surface of the eyeball and is constantly activated with light and various physical stimuli. Humans
are exposed to UV and other light with various wavelengths during daily life. Light ranging from 380 nm to 530 nm comprises
high-energy visible light that is present in sunlight, fluorescent light, and light-emitting diodes (LEDs). In this report,
we investigated the effects of bilberry extract and its anthocyanin constituents on corneal epithelial cell damage induced by
blue LED light. Human corneal epithelial (HCE-T) cells were in the presence of bilberry extract or its anthocyanin constituents
followed by exposure to 2,000 lux of blue LED light. We found that bilberry extract or its anthocyanin constituents (delphinidin
3-glucoside and cyanidin 3-glucoside) reduced cell death, reactive oxygen species (ROS) production and cell dehydrogenase
activity. In addition, bilberry extract inhibited blue LED light-induced changes in the mitochondrial membrane potential
and caspase-3/7 activity, both of which are associated with apoptosis. These findings suggested that bilberry extract or its
constituent anthocyanins have protective effects against blue LED light-induced cell damage by reducing ROS production.
Key words: blue light-emitting diode light, corneal epithelial cells, reactive oxygen species, bilberry, anthocyanin
書誌情報 en : Journal of Nutritional Food

巻 17, 号 1, p. 18-33, 発行日 2020-05-19
DOI
値 10.20618/jhnfa.17.1_18
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