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The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells
https://gifu-pu.repo.nii.ac.jp/records/14149
https://gifu-pu.repo.nii.ac.jp/records/14149a3f78a3a-3fd2-45e7-a813-168d0967c228
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-09-11 | |||||
| タイトル | ||||||
| タイトル | The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | The cornea is located on the surface of the eyeball and is constantly activated with light and various physical stimuli. Humans are exposed to UV and other light with various wavelengths during daily life. Light ranging from 380 nm to 530 nm comprises high-energy visible light that is present in sunlight, fluorescent light, and light-emitting diodes (LEDs). In this report, we investigated the effects of bilberry extract and its anthocyanin constituents on corneal epithelial cell damage induced by blue LED light. Human corneal epithelial (HCE-T) cells were in the presence of bilberry extract or its anthocyanin constituents followed by exposure to 2,000 lux of blue LED light. We found that bilberry extract or its anthocyanin constituents (delphinidin 3-glucoside and cyanidin 3-glucoside) reduced cell death, reactive oxygen species (ROS) production and cell dehydrogenase activity. In addition, bilberry extract inhibited blue LED light-induced changes in the mitochondrial membrane potential and caspase-3/7 activity, both of which are associated with apoptosis. These findings suggested that bilberry extract or its constituent anthocyanins have protective effects against blue LED light-induced cell damage by reducing ROS production. Key words: blue light-emitting diode light, corneal epithelial cells, reactive oxygen species, bilberry, anthocyanin |
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| 書誌情報 |
en : Journal of Nutritional Food 巻 17, 号 1, p. 18-33, 発行日 2020-05-19 |
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| DOI | ||||||
| 値 | 10.20618/jhnfa.17.1_18 | |||||
