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  1. 岐阜藥科大學紀要
  2. 46号(平成9年6月30日発行)

<Regular article>Opioid Receptor Affinities of Tyrosine ω-Phenylalkyl Esters, Simple Enkephalin Pharmacophore-mimics.

https://gifu-pu.repo.nii.ac.jp/records/10777
https://gifu-pu.repo.nii.ac.jp/records/10777
9150b19f-a7d3-4b85-8b27-abb22b76003b
名前 / ファイル ライセンス アクション
KJ00000073463.pdf KJ00000073463.pdf (568.3 kB)
Item type 紀要論文(ELS) / Departmental Bulletin Paper(1)
公開日 1997-06-30
タイトル
言語 en
タイトル <Regular article>Opioid Receptor Affinities of Tyrosine ω-Phenylalkyl Esters, Simple Enkephalin Pharmacophore-mimics.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ページ属性
内容記述タイプ Other
内容記述 P(論文)
著者名(英) IWAMURA, TATSUNORI

× IWAMURA, TATSUNORI

WEKO 21287

en IWAMURA, TATSUNORI

Search repository
TSUTSUI, HISAYOSHI

× TSUTSUI, HISAYOSHI

WEKO 23807

en TSUTSUI, HISAYOSHI

Search repository
KATAOKA, TADASHI

× KATAOKA, TADASHI

WEKO 20983

en KATAOKA, TADASHI

Search repository
HORI, MIKIO

× HORI, MIKIO

WEKO 21314

en HORI, MIKIO

Search repository
NIWA, MASAYUKI

× NIWA, MASAYUKI

WEKO 23808

en NIWA, MASAYUKI

Search repository
NOZAKI, MASAKATSU

× NOZAKI, MASAKATSU

WEKO 21313

en NOZAKI, MASAKATSU

Search repository
著者所属(日)
値 岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/岐阜女子大学/岐阜大学医学部/岐阜大学医学部
著者所属(英)
言語 en
値 Gifu Pharmaceutical University/Gifu Pharmaceutical University/Gifu Pharmaceutical University/Gifu Woman's University/Gifu University, School of Medicine/Gifu University, School of Medicine
抄録(英)
内容記述タイプ Other
内容記述 In order to substantiate the hypothesis that the μ-, δ-, or κ-opioid receptor Affinity of opioid peptides can be elicited by an amino-terminus tyrosine residue and the 4th phenylalanine aromatic ring lying in the proper spatial disposition, a series of simple peptide-mimic tyrosine esters, in which tyrosine is linked to aromatic ring separated by a variety of methylene spacers, were prepared and evaluated by in vitro radioligand receptor assay. Compounds having the 6 or 7 methylene spacers were more potent in opioid receptor affinity than those having fewer or more methylene spacers. The N-monomethyl- and N, N-dimethyltyrosine congeners were more potent than the corresponding tyrosine esters. The order of the receptor type selectivity of these compounds was μ>>δ>κ.
雑誌書誌ID
収録物識別子タイプ NCID
収録物識別子 AN00053514
書誌情報 岐阜藥科大學紀要
en : The annual proceedings of Gifu College of Pharmacy

巻 46, p. 37-46, 発行日 1997-06-30
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