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<Regular article>Opioid Receptor Affinities of Tyrosine ω-Phenylalkyl Esters, Simple Enkephalin Pharmacophore-mimics.
https://gifu-pu.repo.nii.ac.jp/records/10777
https://gifu-pu.repo.nii.ac.jp/records/107779150b19f-a7d3-4b85-8b27-abb22b76003b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000073463.pdf (568.3 kB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 1997-06-30 | |||||
| タイトル | ||||||
| タイトル | <Regular article>Opioid Receptor Affinities of Tyrosine ω-Phenylalkyl Esters, Simple Enkephalin Pharmacophore-mimics. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 著者名(英) |
IWAMURA, TATSUNORI
× IWAMURA, TATSUNORI× TSUTSUI, HISAYOSHI× KATAOKA, TADASHI× HORI, MIKIO× NIWA, MASAYUKI× NOZAKI, MASAKATSU |
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| 著者所属(日) | ||||||
| 値 | 岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/岐阜女子大学/岐阜大学医学部/岐阜大学医学部 | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Gifu Pharmaceutical University/Gifu Pharmaceutical University/Gifu Pharmaceutical University/Gifu Woman's University/Gifu University, School of Medicine/Gifu University, School of Medicine | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In order to substantiate the hypothesis that the μ-, δ-, or κ-opioid receptor Affinity of opioid peptides can be elicited by an amino-terminus tyrosine residue and the 4th phenylalanine aromatic ring lying in the proper spatial disposition, a series of simple peptide-mimic tyrosine esters, in which tyrosine is linked to aromatic ring separated by a variety of methylene spacers, were prepared and evaluated by in vitro radioligand receptor assay. Compounds having the 6 or 7 methylene spacers were more potent in opioid receptor affinity than those having fewer or more methylene spacers. The N-monomethyl- and N, N-dimethyltyrosine congeners were more potent than the corresponding tyrosine esters. The order of the receptor type selectivity of these compounds was μ>>δ>κ. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00053514 | |||||
| 書誌情報 |
岐阜藥科大學紀要 en : The annual proceedings of Gifu College of Pharmacy 巻 46, p. 37-46, 発行日 1997-06-30 |
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